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Table 2 Comparisons between phenotypic and systemic endocrine/metabolic indices Induced by expression of diabetes (db/db) and obese (ob/ob) mutations in C57BL/KsJ mice

From: Influences of obese (ob/ob) and diabetes (db/db) genotype mutations on lumber vertebral radiological and morphometric indices: Skeletal deformation associated with dysregulated systemic glucometabolism

Parameter

Age(weeks)

Controls

Diabetes

Obese

Body Weight (g)

8

21.1 ± 0.3 (16)

*33.7 ± 0.8 (16)

*37.0 ± 1.3 (16)

 

16

25.2 ± 0.5 (12)

*41.0 ± 2.4 (8)

*59.3 ± 1.2 (10)

Blood Glucose (mg/dl)

8

108.6 ± 7.7 (12)

*278.5 ± 22.6 (12)

*178.9 ± 15.4 (12)

 

16

128.3 ± 7.9 (8)

*356.6 ± 37.6 (8)

*150.9 ± 5.8 (8)

Serum Insulin (pg/ml)

8

1184.3 ± 121.4 (12)

*3862.8 ± 231.7 (12)

*2342.9 ± 186.4 (12)

 

16

1386.0 ± 132.0 (8)

*3300.0 ± 181.0 (8)

*2000.0 ± 150.0 (8)

Serum Triglycerides (mg/ml)

8

162.0 ± 18.0 (12)

*300.0 ± 50.0 (12)

*300.0 ± 53.0 (12)

 

16

162.0 ± 24.0 (8)

*300.0 ± 83.0 (8)

*300.0 ± 43.0 (8)

  1. Comparisons between indicated phenotype and systemic endocrine/metabolic parameters in control, diabetes- or obese-mutant C57BK/KsJ mice at 8 and 16 weeks of age are demoted as group means (± SEM) for the designated number (N) of animals per group. Significant (P ≤ 0.05) intergroup differences (i.e. control v.s. genotype group values) at the designated age are indicated by asterisks (*).