Table 4 Number (%) of adverse events
Adverse Event | Topical diclofenac (n = 107) | Vehicle control (n = 109) |
|---|---|---|
Gastrointestinal reaction | ||
Abdominal pain | 4 (3.7) | 1 (0.9) |
Constipation | 1 (0.9) | 1 (0.9) |
Diarrhea | 1 (0.9) | 0 |
Dyspepsia | 4 (3.7) | 1 (0.9) |
Gastritis | 1 (0.9) | 0 |
Melena | 0 | 1 (0.9) |
Nausea | 1 (0.9) | 2 (1.8) |
Application-site skin reaction | ||
Dry skin | 42 (39.3)* | 23 (21.1) |
Rash | 2 (1.9) | 4 (3.7) |
Paresthesia | 2 (1.9) | 2 (1.8) |
Pruritus | 0 | 2 (1.8) |
Other reaction | ||
Headache | 6 (5.6) | 10 (9.2) |
Halitosis | 2 (1.9) | 0 |
Taste Perversion | 4 (3.7) | 2 (1.8) |