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Table 3 Efficacy evaluation of the dichotomous variables

From: Treatment of osteoarthritis of the knee with a topical diclofenac solution: a randomised controlled, 6-week trial [ISRCTN53366886]

Efficacy variables

Treatment group

N

Number (%) of participants

p-value

Number-needed-to-treat (95% CI)

50% reduction in pain

Topical diclofenac

105

46 (43.8)

0.004

5 (3–17)

 

Vehicle control

107

27 (25.2)

  

OMERACT-OARSI responder*

Topical diclofenac

105

69 (65.7)

0.017

6 (3–33)

 

Vehicle control

107

53 (49.5)

  

Good or very good PGA response

Topical diclofenac

105

46 (43.8)

<0.0001

4 (3–7)

 

Vehicle control

107

18 (16.8)

  
  1. *A responder is defined as a participant with ≥ 50% improvement in pain or function that was ≥ 20% of the scale, or ≥ 20% improvement in at least two of pain, function or patient global assessment that was ≥ 10% of the scale.