Treatment of osteoarthritis of the knee with a topical diclofenac solution: a randomised controlled, 6-week trial [ISRCTN53366886]

Table 2 Efficacy evaluation of the continuous variables

Efficacy variable	Treatment group	N	Baseline score, mean (SD)	Change in score mean (SD)	Mean difference in change (95% CI)	P-value	Effect size (95% CI)
Pain	Topical diclofenac	105	13.0 (3.1)	-5.2 (5.0)	1.9 (0.7 to 3.2)	0.003	0.41 (0.14 to 0.68)
	Vehicle control	107	12.7 (3.2)	-3.3 (4.3)
Physical function	Topical diclofenac	105	40.9 (11.9)	-13.4 (16.3)	6.5 (2.5 to 10.5)	0.001	0.44 (0.16 to 0.71)
	Vehicle control	107	40.3 (11.3)	-6.9 (13.2)
Patient global assessment	Topical diclofenac	105	3.1 (0.8)	-1.3 (1.3)	0.6 (0.2 to 0.9)	0.0001	0.47 (0.19 to 0.74)
	Vehicle control	107	3.2 (0.7)	-0.7 (1.1)
Stiffness	Topical diclofenac	105	5.3 (1.4)	-1.8 (2.1)	0.9 (0.3 to 1.4)	0.002	0.43 (0.15 to 0.70)
	Vehicle control	107	5.2 (1.5)	-0.9 (2.0)
Pain on walking	Topical diclofenac	105	2.7 (0.8)	-1.2 (1.2)	0.4 (0.1 to 0.7)	0.014	0.34 (0.07 to 0.61)
	Vehicle control	107	2.7 (0.8)	-0.8 (1.1)

ISSN: 1471-2474