Transforming growth factor beta-1 (TGFB1) and peak bone mass: association between intragenic polymorphisms and quantitative ultrasound of the heel

Table 5 Multiple linear regression analysis of genetic and clinical determinants of QUS-SI modelled to determine individual contribution of -509 and codon10.*

-509				Codon 10
Variables	F-stat	R²	p-value	Variables	F-stat	R²	p-value
Age	6.21	0.072	0.0130	Age	5.68	0.069	0.0175
Caffeine Intake	12.74	0.084	0.0004	Caffeine Intake	9.54	0.077	0.0021
BMI	19.24	0.185	<0.0001	BMI	18.75	0.185	<0.0001
Active as adolescent	7.46	0.107	0.0065	Active as Adolescent	9.06	0.120	0.0027
Currently Active	8.51	0.082	0.0037	Currently active	7.43	0.078	0.0066
Relatives with Osteoporosis	1.98	0.008	0.1598	Relatives with Osteoporosis	1.95	0.007	0.1627
^§-509 SNP	3.18	0.056	0.0422	^§Codon 10	3.32	0.062	0.0369

*Shown for each dependent variable are the individual F-statistics (F-stat), the variance attributable to that variable (R², based on Type III sum of squares), and the significance (p-value).
^§ The -509 and codon10 SNPS are significant (P <0.05) when added to the previously reported model [6]

ISSN: 1471-2474