TY - JOUR AU - Najm, Wadie I. AU - Reinsch, Sibylle AU - Hoehler, Fred AU - Tobis, Jerome S. AU - Harvey, Phillip W. PY - 2004 DA - 2004/02/26 TI - S-Adenosyl methionine (SAMe) versus celecoxib for the treatment of osteoarthritis symptoms: A double-blind cross-over trial. [ISRCTN36233495] JO - BMC Musculoskeletal Disorders SP - 6 VL - 5 IS - 1 AB - S-Adenosylmethionine (SAMe) is a dietary supplement used in the management of osteoarthritis (OA) symptoms. Studies evaluating SAMe in the management of OA have been limited to Non Steroidal Anti-inflammatory Drugs (NSAIDs) for comparison. The present study compares the effectiveness of SAMe to a cyclooxygenase-2 (COX-2) inhibitor (celecoxib) for pain control, functional improvement and to decrease side effects in people with osteoarthritis of the knee. SN - 1471-2474 UR - https://doi.org/10.1186/1471-2474-5-6 DO - 10.1186/1471-2474-5-6 ID - Najm2004 ER -