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Table 2 Placebo contolled trials

From: Topical NSAIDs for chronic musculoskeletal pain: systematic review and meta-analysis

  Number of Events/total  
Type of adverse event Trials Patients Treatment Placebo RR (95% CI)
Local adverse events 15 1734 53/949 48/785 1.0 (0.7 to 1.4)
Systemic adverse events 16 1838 33/1002 14/836 1.7 (0.96 to 2.85)
Withdrawals beacuse of adverse events 10 1225 10/697 7/528 0.9 (0.4 to 2.1)
Active controlled trials: topical vs oral
  Number of Events/total  
Type of adverse event Trials Patients Treatment Placebo RR (95% CI)
Local adverse events 2 443 19/243 4/118 3.0 (1.1 to 8.5)
Systemic adverse events 3 764 82/408 87/356 0.83 (0.6 to 1.1)
Withdrawals because of adverse events 3 764 19/408 24/356 0.7 (0.4 to 1.3)