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Table 1 Summary data and sensitivity analyses for placebo controlled trials

From: Topical NSAIDs for chronic musculoskeletal pain: systematic review and meta-analysis

  Number of Success/total   
Trial characteristic Trials Patients Treatment Placebo RB (95% CI) NNT (95% CI)
All trials 14 1502 371/771 193/731 1.9 (1.7 to 2.2) 4.6 (3.8 to 5.9)
Quality and validity       
Quality score 3 to 5 11 1312 294/678 144/634 2.0 (1.7 to 2.4) 4.8 (3.9 to 6.4)
Quality score 2 3 190 77/93 49/97 1.6 (1.3 to 2.0) 3.1 (2.2 to 5.1)
Validity score ≥ 9 and quality score ≥ 3 10 1197 247/622 98/575 2.4 (2.0 to 3.0) 4.4 (3.6 to 5.6)
Trial group size       
≤ 50 patients 6 343 95/172 54/171 1.8 (1.4 to 2.3) 4.2 (3.0 to 7.4)
> 50 patients 8 1159 276/599 139/560 2.0 (1.7 to 2.3) 4.7 (3.8 to 6.3)
Outcome type       
preferred outcomes 8 920 198/462 85/458 2.3 (1.9 to 2.9) 4.1 (3.3 to 5.4)
lower preference outcomes 6 582 173/309 108/273 1.6 (1.4 to 1.9) 6.1 (4.1 to 12)
Condition       
knee osteoarthritis 5 567 127/307 58/260 2.0 (1.6 to 2.6) 5.3 (3.8 to 8.6)
other musculoskeletal 9 935 244/464 135/471 1.9 (1.6 to 2.2) 4.2 (3.3 to 5.6)