Does simvastatin stimulate bone formation in vivo?

Table 1 Control Data Throughout the Course of the Study

Parameter	OVX T1	Sham T1	OVX T1	OVX T5	Sham T5	OVX T5	OVX T13	Sham T13	OVX T13
	(n = 9)	(n = 9)	vs. Sham T1	(n = 9)	(n = 9)	vs. Sham T5	(n = 9)	(n = 9)	vs. Sham T13
	Assessment at 1 Week		p-value	Assessment at 5 Weeks		p-value	Assessment at 13 Weeks		p-value
Full BV/TV (%)	69 ± 3	72 ± 2	<0.001	67 ± 2	75 ± 3	<0.001	67 ± 3	75 ± 3	<0.001
Tb.BV/TV (%)	15 ± 6	26 ± 5	<0.001	5 ± 3	28 ± 12	<0.001	5 ± 4	34 ± 11	<0.001
Tb.Th (mm)	0.08 ± 0.01	0.1 ± 0.01	<0.001	0.06 ± 0.01	0.10 ± 0.01	<0.001	0.06 ± 0.01	0.11 ± 0.02	<0.001
Tb.Sp (mm)	0.28 ± 0.50	0.28 ± 0.05	NS	0.66 ± 0.16	0.28 ± 0.12	<0.001	0.62 ± 0.21	0.24 ± 0.61	<0.001
Tb.N (1/mm)	3.7 ± 0.6	3.7 ± 0.5	NS	1.6 ± 0.5	3.9 ± 0.9	<0.001	1.9 ± 0.9	4.2 ± 0.7	<0.001
Tb.Conn (1/mm³)	17 ± 11	28 ± 7	NS	4 ± 3	24 ± 8	<0.001	5 ± 4	27 ± 9	<0.001
Ct.TV (mm³)	1.9 ± 0.2	1.9 ± 0.3	NS	1.9 ± 0.2	1.9 ± 0.1	NS	1.9 ± 0.1	2.0 ± 0.2	NS
Ct.MV/TV (%)	56 ± 3	52 ± 3	0.02	50 ± 3	51 ± 3	NS	49 ± 3	47 ± 4	NS
Ct.Th (mm)	0.22 ± 0.02	0.25 ± 0.03	NS	0.26 ± 0.02	0.26 ± 0.02	NS	0.26 ± 0.02	0.29 ± 0.04	NS

Plus-minus values represent the mean ± standard deviation. Statistical analysis was performed by ANOVA with post-hoc multiple comparisons using the Fisher least significant difference (LSD) method. T1 = sacrificed after 1 week; T5 = sacrificed after 5 weeks; T13 = sacrificed after 13 weeks. Vehicle-treated animals. NS = not significant; Full BV/TV: Whole Bone Volume Density; Tb. BV/TV: Trabecular Bone Volume Density; Tb.Th: Trabecular Thickness; Tb.Sp: Trabecular Spacing; Tb.N: Trabecular Number; Ct.TV: Cortical Total Volume; Ct.MV/TV: Cortical Marrow Volume Density; Ct.Th: Cortical Thickness.

ISSN: 1471-2474