Skip to main content

Table 1 Control Data Throughout the Course of the Study

From: Does simvastatin stimulate bone formation in vivo?

Parameter OVX T1 Sham T1 OVX T1 OVX T5 Sham T5 OVX T5 OVX T13 Sham T13 OVX T13
  (n = 9) (n = 9) vs. Sham T1 (n = 9) (n = 9) vs. Sham T5 (n = 9) (n = 9) vs. Sham T13
  Assessment at 1 Week p-value Assessment at 5 Weeks p-value Assessment at 13 Weeks p-value
Full BV/TV (%) 69 ± 3 72 ± 2 <0.001 67 ± 2 75 ± 3 <0.001 67 ± 3 75 ± 3 <0.001
Tb.BV/TV (%) 15 ± 6 26 ± 5 <0.001 5 ± 3 28 ± 12 <0.001 5 ± 4 34 ± 11 <0.001
Tb.Th (mm) 0.08 ± 0.01 0.1 ± 0.01 <0.001 0.06 ± 0.01 0.10 ± 0.01 <0.001 0.06 ± 0.01 0.11 ± 0.02 <0.001
Tb.Sp (mm) 0.28 ± 0.50 0.28 ± 0.05 NS 0.66 ± 0.16 0.28 ± 0.12 <0.001 0.62 ± 0.21 0.24 ± 0.61 <0.001
Tb.N (1/mm) 3.7 ± 0.6 3.7 ± 0.5 NS 1.6 ± 0.5 3.9 ± 0.9 <0.001 1.9 ± 0.9 4.2 ± 0.7 <0.001
Tb.Conn (1/mm3) 17 ± 11 28 ± 7 NS 4 ± 3 24 ± 8 <0.001 5 ± 4 27 ± 9 <0.001
Ct.TV (mm3) 1.9 ± 0.2 1.9 ± 0.3 NS 1.9 ± 0.2 1.9 ± 0.1 NS 1.9 ± 0.1 2.0 ± 0.2 NS
Ct.MV/TV (%) 56 ± 3 52 ± 3 0.02 50 ± 3 51 ± 3 NS 49 ± 3 47 ± 4 NS
Ct.Th (mm) 0.22 ± 0.02 0.25 ± 0.03 NS 0.26 ± 0.02 0.26 ± 0.02 NS 0.26 ± 0.02 0.29 ± 0.04 NS
  1. Plus-minus values represent the mean ± standard deviation. Statistical analysis was performed by ANOVA with post-hoc multiple comparisons using the Fisher least significant difference (LSD) method. T1 = sacrificed after 1 week; T5 = sacrificed after 5 weeks; T13 = sacrificed after 13 weeks. Vehicle-treated animals. NS = not significant; Full BV/TV: Whole Bone Volume Density; Tb. BV/TV: Trabecular Bone Volume Density; Tb.Th: Trabecular Thickness; Tb.Sp: Trabecular Spacing; Tb.N: Trabecular Number; Ct.TV: Cortical Total Volume; Ct.MV/TV: Cortical Marrow Volume Density; Ct.Th: Cortical Thickness.