TY - JOUR AU - Howard, Jeffrey C. AU - Varallo, Vincenzo M. AU - Ross, Douglas C. AU - Roth, James H. AU - Faber, Kenneth J. AU - Alman, Benjamin AU - Gan, Bing Siang PY - 2003 DA - 2003/07/16 TI - Elevated levels of β-catenin and fibronectin in three-dimensional collagen cultures of Dupuytren's disease cells are regulated by tension in vitro JO - BMC Musculoskeletal Disorders SP - 16 VL - 4 IS - 1 AB - Dupuytren's contracture or disease (DD) is a fibro-proliferative disease of the hand that results in the development of scar-like, collagen-rich disease cords within specific palmar fascia bands. Although the molecular pathology of DD is unknown, recent evidence suggests that β-catenin may play a role. In this study, collagen matrix cultures of primary disease fibroblasts show enhanced contraction and isometric tension-dependent changes in β-catenin and fibronectin levels. SN - 1471-2474 UR - https://doi.org/10.1186/1471-2474-4-16 DO - 10.1186/1471-2474-4-16 ID - Howard2003 ER -