| Placebo | Simvastatin 20 | Simvastatin 40 | ||||||
---|---|---|---|---|---|---|---|---|---|
 | Baseline | 6 weeks | 12 weeks | Baseline | 6 weeks | 12 weeks | Baseline | 6 weeks | 12 weeks |
NTX-I, nM BCE | 15.5 ± 1.8 | 15.7 ± 2.0 | 15.9 ± 1.4 | 16.5 ± 1.7 | 15.9 ± 1.2 | 19.6 ± 1.8 | 19.3 ± 2.4 | 17.6 ± 2.1 | 18.1 ± 2.0 |
CTX-I, ng/ml | 95.4 ± 5.9 | 86.4 ± 7.9 | 86.9 ± 11.5 | 90.3 ± 10.1 | 83.2 ± 12.1 | 107.2 ± 18.8 | 108.2 ± 11.3 | 94.2 ± 14.1 | 120.7 ± 12.2 |
Bone ALP, U/L | 14.3 ± 2.4 | 14.0 ± 2.5 | 14.4 ± 2.9 | 19.0 ± 3.0 | 17.4 ± 2.8 | 17.2 ± 2.8 | 14.3 ± 2.2 | 13.4 ± 2.2 | 14.0 ± 2.2 |