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Table 3 Effect of 1,25-(OH)2D3 on osteoclastic parameters in fourth lumbar vertebral trabecular bone

From: Recruitment, augmentation and apoptosis of rat osteoclasts in 1,25-(OH)2D3 response to short-term treatment with 1,25-dihydroxyvitamin D3 in vivo

Exp Dose Time N.Oc/T.Ar (#/mm2) N.Oc/B.Pm (#/mm) N.ApOc/T.Ar (#/mm2)
    Vehicle 1,25-(OH)2D3 Vehicle 1,25-(OH)2D3 Vehicle 1,25-(OH)2D3
2 3 × 10 μg/kg 4 d 33.9 ± 5.0 66.4 ± 5.5* 3.9 ± 0.7 7.7 ± 1.0* 0 4.6 ± 1.3*
3 3 × 2 μg/kg 4 d 31.0 ± 1.7 56.3 ± 3.3* 3.5 ± 0.4 6.9 ± 0.4* 0.5 ± 0.3 3.1 ± 0.4*
   6 d 35.0 ± 4.2 16.7 ± 0.6* 4.1 ± 0.5 3.3 ± 0.1* 0.7 ± 0.2 3.5 ± 0.3*
   9 d 30.6 ± 7.3 33.9 ± 4.7 3.8 ± 0.8 3.9 ± 0.7 0.7 ± 0.2 0.7 ± 0.2
   13 d 26.7 ± 2.4 46.9 ± 4.8* 2.9 ± 0.4 5.1 ± 0.3* 0.7 ± 0.2 1.2 ± 0.4
   17 d 30.3 ± 5.0 44.0 ± 4.5 3.5 ± 0.3 4.6 ± 0.6 0.5 ± 0.2 1.0 ± 0.3
4 3 × 0.2 μg/kg 4 d 28.8 ± 1.9 27.3 ± 1.9 3.0 ± 0.2 2.7 ± 0.2 0.2 ± 0.2 0
   6 d 28.2 ± 1.5 27.1 ± 2.6 3.0 ± 0.1 3.0 ± 0.2 0.2 ± 0.2 0
   8 d 26.9 ± 2.8 29.2 ± 2.2 2.9 ± 0.2 3.2 ± 0.4 0 0.4 ± 0.2
   10 d 29.4 ± 2.4 31.7 ± 2.3 3.7 ± 0.1 3.1 ± 0.3 0.2 ± 0.2 0.4 ± 0.2
   12 d 31.5 ± 2.7 32.5 ± 3.3 3.3 ± 0.3 3.6 ± 0.3 0.2 ± 0.2 0.2 ± 0.2
   14 d 30.6 ± 3.2 29.8 ± 2.7 3.5 ± 0.3 3.5 ± 0.3 0 0.2 ± 0.2
  1. All values are mean ± SE, *: P < 0.05