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Table 2 Effect of 1,25-(OH)2D3 on Osteoclastic parameters in rat tibial trabecular bone

From: Recruitment, augmentation and apoptosis of rat osteoclasts in 1,25-(OH)2D3 response to short-term treatment with 1,25-dihydroxyvitamin D3 in vivo

Exp Dose Time N.Oc/T.Ar (#/mm2) N.Oc/B.Pm (#/mm) N.ApOc/T.Ar (#/mm2)
    Vehicle 1,25-(OH)2D3 Vehicle 1,25-(OH)2D3 Vehicle 1,25-(OH)2D3
1 1 × 10 μg/kg 1 d 63.1 ± 2.0 61.7 ± 2.9 6.0 ± 0.5 6.4 ± 0.8 0.7 ± 0.3 1.0 ± 0.6
2 3 × 10 μg/kg 4 d 76.7 ± 2.4 65.7 ± 3.8 7.5 ± 0.1 6.3 ± 0.3 1.0 ± 0.6 11.7 ± 0.9*
3 3 × 2 μg/kg 4 d 75.0 ± 6.3 111.0 ± 2.0* 7.0 ± 0.3 9.7 ± 5.3* 0.3 ± 0.3 10.3 ± 0.7*
   6 d 85.1 ± 9.5 41.3 ± 12.9* 8.4 ± 0.5 3.2 ± 1.1* 1.0 ± 0.6 5.0 ± 0.6*
   9 d 91.9 ± 10. 98.4 ± 9.8 8.8 ± 0.7 8.8 ± 0.6 0.7 ± 0.3 0.7 ± 0.3
   13 d 9 81.1 ± 4.5 8.9 ± 1.2 6.7 ± 0.7 0.7 ± 0.3 0.3 ± 0.3
   17 d 71.0 ± 5.3 73.9 ± 2.6 6.5 ± 0.2 6.5 ± 0.4 0.7 ± 0.3 1.0 ± 0.6
    73.5 ± 2.2      
4 3 × 0.2 μg/kg 4 d 39.2 ± 4.9 33.4 ± 3.0 3.5 ± 0.3 3.9 ± 0.2 0.4 ± 0.2 0.6 ± 0.2
   6 d 32.9 ± 2.4 45.1 ± 4.1* 3.8 ± 0.3 5.1 ± 0.7* 0.6 ± 0.2 1.0 ± 0.3
   8 d 37.6 ± 5.6 23.4 ± 2.1* 5.2 ± 0.7 3.1 ± 0.2* 0.4 ± 0.2 1.6 ± 0.2*
   10 d 35.5 ± 3.4 40.9 ± 3.5 5.2 ± 0.5 4.6 ± 0.6 0.4 ± 0.2 0.8 ± 0.4
   12 d 36.9 ± 5.0 39.0 ± 7.9 4.6 ± 0.3 4.5 ± 0.4 0.4 ± 0.2 0.6 ± 0.2
   14 d 41.1 ± 3.9 37.5 ± 1.3 5.7 ± 0.5 4.9 ± 0.4 0.2 ± 0.2 0.4 ± 0.2
  1. All values are mean ± SE, *: P < 0.05