|
Variables
|
Continuous ferritin levels
|
Dichotomized ferritin levels
|
|---|
|
Mean ± SD ng/ml
|
P value*
|
Odds ratio [95% CI]
|
P value**
|
|---|
|
OA patients ( N = 127)
|
59.1 ± 114.9
|
0.334
|
2.21 [0.71–8.25]
|
0.151
|
|
Healthy controls ( N = 20)
|
37.07 ± 22.98
| | | |
|
Age >56 years ( N = 109)
¶
|
62.5 ± 121.7
|
0.0186
|
2.31 [0.94– 6.15]
|
0.050
|
|
Age ≤56 years ( N = 38)
|
35.6 ± 22.8
| | | |
|
Female ( N = 89)
|
51.94 ± 133.5
|
0.0006
|
2.8 [1.34– 5.9]
|
0.0034
|
|
Male ( N = 58)
|
62.49 ± 43.7
| | | |
|
White ( N = 97)
|
57.7 ± 128.9
| |
0.78 [0.37–1.7]
|
0.595
|
|
Asian ( N = 13)
|
48.52 ± 33.9
|
0.727
| | |
|
African American ( N = 37)
|
54.4 ± 44.8
|
0.411
| | |
|
Genotype:
| | | | |
|
+/+ ( N = 110)
|
47.4 ± 38.7
|
Reference
| | |
|
H63D/+ ( N = 23)
|
43.0 ± 37.1
|
0.529***
|
1.2 [0.44–3.38]
|
0.646
|
|
C282Y/+ ( N = 7)
|
44.2 ± 34.8
|
0.951***
|
0.65 [0.06– 4.19]
|
0.709
|
|
H63D/H63D ( N = 2)
|
21.3 ± 11.6
|
0.401***
| |
NA
|
|
C282Y/H63D ( N = 2)
|
75.3 ± 6.6
|
0.210***
| |
NA
|
|
C282Y/C282Y ( N = 3)
|
513.6 ± 646.9
|
0.00006***
| |
NA
|
- Data are presented as mean ± standard deviation (SD).
- P values refer to difference between two groups as derived from:
- *t test on log-transformed ferritin.
- **Chi-square test.
-
¶Cut-off based on mean age of healthy controls.
- ***+/+ (wild type) versus mutation.
