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Table 3 Univariate analyses of ferritin levels at entry after natural log (Ln) transformation according to diseases, age, sex, race, and genotype at entry

From: Age-dependent ferritin elevations and HFE C282Y mutation as risk factors for symptomatic knee osteoarthritis in males: a longitudinal cohort study

Variables Continuous ferritin levels Dichotomized ferritin levels
Mean ± SD ng/ml P value* Odds ratio [95% CI] P value**
OA patients ( N= 127) 59.1 ± 114.9 0.334 2.21 [0.71–8.25] 0.151
Healthy controls ( N= 20) 37.07 ± 22.98    
Age >56 years ( N= 109) 62.5 ± 121.7 0.0186 2.31 [0.94– 6.15] 0.050
Age ≤56 years ( N= 38) 35.6 ± 22.8    
Female ( N= 89) 51.94 ± 133.5 0.0006 2.8 [1.34– 5.9] 0.0034
Male ( N= 58) 62.49 ± 43.7    
White ( N= 97) 57.7 ± 128.9   0.78 [0.37–1.7] 0.595
Asian ( N= 13) 48.52 ± 33.9 0.727   
African American ( N= 37) 54.4 ± 44.8 0.411   
Genotype:     
  +/+ ( N= 110) 47.4 ± 38.7 Reference   
  H63D/+ ( N= 23) 43.0 ± 37.1 0.529*** 1.2 [0.44–3.38] 0.646
  C282Y/+ ( N= 7) 44.2 ± 34.8 0.951*** 0.65 [0.06– 4.19] 0.709
  H63D/H63D ( N= 2) 21.3 ± 11.6 0.401***   NA
  C282Y/H63D ( N= 2) 75.3 ± 6.6 0.210***   NA
  C282Y/C282Y ( N= 3) 513.6 ± 646.9 0.00006***   NA
  1. Data are presented as mean ± standard deviation (SD).
  2. P values refer to difference between two groups as derived from:
  3. *t test on log-transformed ferritin.
  4. **Chi-square test.
  5. Cut-off based on mean age of healthy controls.
  6. ***+/+ (wild type) versus mutation.