Table 2 Severity of symptomatic knee osteoarthritis (SKOA) according to clinical and radiographic measures: pain visual analog scale (VAS) and Western Ontario and McMaster Osteoarthritis Index (WOMAC) scores at baseline; change in Kellgren-Lawrence (KL) grade from baseline to 24 months; joint space width (JSW) at baseline and 24 months; and progression of joint space narrowing (JSN) at 24 months

VAS Pain, mean ± SD (0-100 mm)

40.21 ± 24.6

42.3 ± 24.5

37.4 ± 29.6

WOMAC, mean ± SD

170.25 ± 105.2

173.6 ± 104.2

164.5 ± 107.6

KL delta from baseline to 24 months, N (%)

-1

3 (2.5%)

2 (2.6%)

1 (2.3%)

0

88 (73.3%)

56 (73.7%)

32 (72.7%)

1

26 (21.6%)

16 (21.1%)

10 (22.7%)

2

2 (1.7%)

2 (2.6%)

0

3

1 (8.3%)

0

1 (2.3%)

JSW at baseline, mean ± SD (mm)

3.272 ± 1.766

3.603 ± 1.58

2.7 ± 1.93

JSW at 24 months, mean ± SD (mm)

2.989 ± 1.761

3.388 ± 1.513

2. 3 ± 1.956

JSN over 24 months, mean ± SD (mm)

0.283 ± 0.996

0.21 ± 0.88

0.4 ± 1.16