Age-dependent ferritin elevations and HFE C282Y mutation as risk factors for symptomatic knee osteoarthritis in males: a longitudinal cohort study

Table 1 Comparisons of demographic and clinical characteristics of patients with osteoarthritis (OA) and healthy individuals (control) at baseline, and of ferritin levels at baseline and 18-month follow-up

Variables: All Subjects (N = 147)	Control (N = 20)	OA (N = 127)	P Value*
Age (years), mean ± SD	56.1 ± 9.0	65.1 ± 10.0	0.00034**
Female gender, number (%)	9 (45%)	80 (63.0%)	0.1446***
Caucasian race, number (%)	11 (55%)	86 (67.7%)	0.5099***
Ethnicity:
Hispanic, number (%)	4 (20%)	14 (11.0%)	0.4405***
Non-Hispanic, number (%)	16 (80%)	113 (89.0%)
BMI (kg/m²), mean ± SD	26.6 ± 4.1	26.6 ± 3.6	0.9547**
Genotypes, number (%):
+/+ (wild type)	15 (75%)	95 (74.8%)	0.7962***
H63D/+	5 (25%)	18 (14.2%)
C282Y/+	0	7 (5.5%)
H63D/H63D	0	2 (1.6%)
C282Y/H63D	0	2 (1.6%)
C282Y/C282Y	0	3 (2.4%)
Ferritin (ng/ml), mean ± SD:
Baseline	37.1 ± 23.0	59.1 ±114.9	0.3344**
18-month follow-up	47.7 ± 34.5	53.3 ± 55.8	0.7747**
Delta	8.8 ± 24.8	-6.6 ± 88.8	0.3317**
Variables: Male Subjects ( N = 58)	Control ( N = 11)	OA ( N = 47)	P Value*
Age (years), mean ± SD	58.4 ± 10.1	67.1 ± 9.7	0.0205**
Caucasian race, number (%)	6 (54.5%)	34 (72.3%)	0.2901
Ethnicity:
Hispanic, number (%)	2 (18.2%)	14 (8.5%)	0.3178
BMI (kg/m²), mean ± SD	27.7 ± 3.5	26.6 ± 3.1	0.3716

*P, comparison between OA group and healthy controls by **two-sample t-test or ***Chi-square test.

ISSN: 1471-2474