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Table 2 Summary of Seropositivity in the Twins and Healthy Controls

From: Twins discordant for myositis and systemic lupus erythematosus show markedly enriched autoantibodies in the affected twin supporting environmental influences in pathogenesis

Autoantigena

Seropositive matched control

Seropositive unaffected

Seropositive affected

Fischer’s exact testing unaffected vs. affected

Reference/comment

 

N = 31

N = 31

N = 31

  

Ro52

0

0

6

P = 0.024

[24, 28]

Ro60

0

0

5

NS

[24, 28]

U1-70 K

0

0

5

NS

[28]

RNP-A

0

0

5

NS

[28]

La

0

0

2

NS

[24, 28]

Smith

1

0

3

NS

[28]

Jo-1

0

0

0

NS

[24]

Ku

0

0

2

NS

New

PML

0

0

2

NS

New

P0

0

0

0

NS

New

Trim-28

0

0

0

NS

New

TPO

1

1

0

NS

[24, 25]

TGM2

1

1

0

NS

[28]

ATP4B

0

0

5b

NS

[24, 25]

IL-1α

1

0

1

NS

[23, 35]

IFN-α

0

0

1

NS

[23, 28, 35]

IFN-Îł

2

1

1

NS

[23, 28, 35]

IFN-ω

0

0

0

NS

[23, 28, 35]

TNF-β

0

0

1

NS

[23, 35]

GMCSF

0

0

0

NS

[23, 35]

IL-17

0

0

0

NS

[23, 35]

Total

6 c

3 c

13 c

P = 0.0078

 
  1. aAntigens tested in blinded fashion are bolded.
  2. bAll 5 seropositive subjects were from DM affected twins.
  3. CTotal number of seropositive subjects in each group.