Characteristics | Patient 1 | Patient 2 | Patient 3 | Patient 4 | Patient 5 | Patient 6 | Patient 7 | Patient 8 | Patient 9 | Patient 10 | Patient 11 | Patient 12 | Patient 13 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Age/Gender | 53/M | 39/F | 42/F | 54/F | 71/F | 26/F | 45/F | 55/F | 36/F | 54/M | 17/F | 21/M | 51/F |
Past history of hepatitis | no | yes | no | no | no | yes | no | no | no | yes | yes | yes | yes |
HBeAg, baseline/reactivation | -/- | -/- | -/- | -/- | -/- | -/- | +/+ | -/- | -/- | -/- | +/+ | +/+ | -/- |
Viral loads at baseline (Copies/mL) | <103 | <103 | <103 | 1.0 × 103 | <103 | <103 | <103 | <103 | 7.03 × 103 | 1.22 × 103 | 3.18 × 105 | <103 | 1.0 × 103 |
Viral loads at reactivation (Copies/mL) | 3.64 × 105 | 7.87 × 103 | 1.92 × 103 | 2.47 × 104 | 6.98 × 103 | 1.15 × 104 | 3.01 × 103 | 4.01 × 103 | 9.91 × 105 | 1.41 × 107 | 1.78 × 108 | 5.26 × 107 | 1.59 × 107 |
ALT at baseline (U/L) | 8 | 8 | 20 | 19 | 10 | 6 | 15 | 15 | 11 | 30 | 17 | 20 | 27 |
ALT at reactivation (U/L) | 26 | 20 | 39 | 24 | 26 | 8 | 16 | 123 | 103 | 103 | 825 | 1880 | 1274 |
Therapeutic regimens during follow-up | |||||||||||||
Corticosteroid | 7.5-10 mg/d | no | no | 2.5-10 mg/d | 5-10 mg/d | 10 mg/d | 10 mg/d | 2.5-10 mg/d | 10 mg/d | 7.5-10 mg/d | 7.5-10 mg/d | no | 5-7.5 mg/d |
DMARDs | MTX + LEF | MTX + HCQ + SSZ | MTX + LEF | MTX + HCQ | MTX + SSZ | LEF | MTX + HCQ + SSZ | MTX + LEF | MTX + HCQ + SSZ | MTX + HCQ | MTX + LEF | LEF | MTX + HCQ + SSZ |
Antiviral prophylaxis | no | Dis | no | Dis | Dis | no | no | no | LAM | LAM | Dis | Dis | no |
Time to reactivation (months) | 22 | 24 | 26 | 15 | 10 | 18 | 3 | 22 | 8 | 14 | 5 | 6 | 25 |
Follow-up period (months) | 33 | 43 | 34 | 25 | 22 | 35 | 6 | 52 | 10 | 18 | 11 | 7 | 25 |
HBV hepatitis | no | no | no | no | no | no | no | Anicteric | Anicteric | Anicteric | Icteric | Icteric | Icteric, cirrhosis |
Treatment adjustment after HBV reactivation | |||||||||||||
Adjustments in DMARDs | MTX + HCQ + SSZ | no | no | no | no | no | no | HCQ | MTX + HCQ + SSZ | HCQ | SSZ | HCQ | withdrawal |
Antiviral drugs | LAM | no | no | no | no | no | no | LAM | Adefovir dipivoxil | telbivudine | LAM | entecavir | telbivudine |