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Table 2 Characteristics of included studies

From: Effectiveness of tranexamic acid in reducing blood loss in spinal surgery: a meta-analysis

Study Type Intervation Surgery Outcome measure Complication Indication of transfusion Jadad’ score
Neilipovitz DT, 2001 [15] RCT I: 10 mg/kg Posterior spinal fusion for scoliosis, 16 pts accepted autologous bone harvest Blood loss, blood transused, Hb, Plt, PTT, DVT 0 Hb ≤ 7 g/L 5
M: 1 mg/kg/h
P: Unclear
Sethna NF, 2005 [16] RCT I: 100 mg/kg Thirty six pts for posterior spinal instrumentation and 8 for anterior–posterior instrumentation Blood loss, blood transused, Hct, PT, Plt, PTT, DVT 0 Hct ≤ 25% 5
M: 10 mg/kg/h
P: Saline
Wong J, 2008 [17] RCT I: 10 mg/kg Thoracic, thoracolumbar or lumbar spinal decompression and instrumented fusion Blood loss, blood transused, Hb, PT, PTT, DVT TXA: 1 pts MI Hb ≤ 7 g/L 5
M: 1 mg/kg/h P: 1 pts DVT
P: Saline  
Elwatidy S, 2008 [19] RCT I: 2 g for adouts, 30 mg/kg for children Eighteen pts had multiple level anterior cervical discectomy with or without fixation, 37 had spinal decompression for multisegment spinal stenosis, 9 had laminectomy and excision of spinal tumor Blood loss, blood transused, Hb, Hct, DVT 0 Hb ≤ 9 g/L 5
M: 100 mg/h for adouts, 1 mg/kg/h for children Hct ≤ 27%
P: Saline
Farrokhi MR, 2011 [18] RCT I: 10 mg/kg Posterior thoracic or lumbar instrumented spinal fusion at 4 to 6 vertebrae Blood loss, blood transused, Hb, PT, PTT, DVT 0 Hb ≤ 10 g/L 5
M: 1 mg/kg/h
P: Saline
Tsutsumimoto T, 2011 [20] RCT I: 15 mg/kg Cervical laminoplasty from C3 to C6 Blood loss, Hb, Hct, PT, PTT, DVT, hematoma formation 0 Not mention 4
P: Saline
  1. Pts, patients; I, initiation dose of tranexamic acid; M, maintenance dose of tranexamic acid; P, placebo; Hb, hemoglobin; Plt, platelets; Hct, hematocrit; PT, prothrombin time; PTT, partial thromboplastin time; MI, myocardial infarction; DVT, deep venous thrombosis.