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Table 1 Main characteristics and methodological quality of all eligible studies

From: Elevated VEGF levels contribute to the pathogenesis of osteoarthritis

First author Year Country Language Ethnicity Gender (M/F) Age (years) Method Protein Sample source NOS score
Case Control Case Control
Saetan et al.[18] 2013 Thailand English Asians 17/63 5/15 69.8 ± 0.9 68.2 ± 1.1 ELISA VEGF Plasma 7
Zhu et al.[26] 2012 China Chinese Asians 8/10 6/4 65 22 ELISA VEGF Synovial fluid 6
Duan et al.[24] 2011 China English Asians 8/22 6/4 62 (50 ~ 76) 32 ELISA VEGF Synovial tissue 6
Huh et al.[28] 2010 Korea English Asians - - 74.0 ± 9.0 61.5 ± 15.6 ELISA VEGF Cartilaginous tissue 5
Chen et al.[23] 2009 China Chinese Asians 11/19 7/1 (52 ~ 75) (21 ~ 43) ELISA VEGF Synovial tissue 6
Su et al.[25] 2008 China Chinese Asians 8/12 7/3 60 45 ELISA VEGF Cartilaginous tissue 6
Fay et al.[3] 2006 Germany English Caucasians - - - - ELISA VEGF Synovial fluid 5
Enomoto et al.[27] 2003 Japan English Asians - - 72.0 ± 8.0 79.0 ± 9.0 ELISA VEGF Cartilaginous tissue 5
Pfander et al.[30] 2001 Germany English Caucasians - - - - ELISA VEGF Cartilaginous tissue 5
Lee et al.[29] 2001 Korea English Asians 4/45 - 59.6 ± 1.1 - ELISA VEGF Plasma 5
Ballara et al.[19] 2001 Germany English Caucasians 15/17 11/20 55 (50 ~ 65) 49 (38 ~ 55) ELISA VEGF Plasma 6
  1. M: male; F: female; NOSF: Newcastle-Ottawa Scale; VEGF: vascular endothelial growth factor; ELISA: enzyme-linked immunosorbent assay.