TY - JOUR AU - Alvarez, Karl AU - de Andrés, María C. AU - Takahashi, Atsushi AU - Oreffo, Richard O. C. PY - 2014 DA - 2014/12/15 TI - Effects of hypoxia on anabolic and catabolic gene expression and DNA methylation in OA chondrocytes JO - BMC Musculoskeletal Disorders SP - 431 VL - 15 IS - 1 AB - Cartilage is an avascular and aneural tissue. Chondrocytes thrive in this restricted environment of low oxygen tension and poor nutrient availability which has led to suggestions that hypoxia may be a protective mechanism against the development of osteoarthritis (OA). There is also a growing body of evidence to support the role of epigenetic factors in the pathogenesis of OA. However, few studies have investigated the epigenetic-OA process within a hypoxic environment. The current study has investigated the effects of hypoxia on gene expression and DNA methylation of anabolic and catabolic genes involved in the pathogenesis of OA. SN - 1471-2474 UR - https://doi.org/10.1186/1471-2474-15-431 DO - 10.1186/1471-2474-15-431 ID - Alvarez2014 ER -