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Table 2 Percentage inhibition in area under the curve values normalized to non-arthritic and SCW vehicle groups for inflammation and mechanical pain in flare 2 for the experiment illustrated in Figure 3 *

From: Etanercept ameliorates inflammation and pain in a novel mono-arthritic multi-flare model of streptococcal cell wall induced arthritis

 

Inflammation (ankle diameter)

Pain (withdrawal threshold)

Prophylactic

Therapeutic

Prophylactic

Therapeutic

Etanercept 0.25 mg/kg

70% (P < 0.001)

44% (P < 0.001)

37% (P < 0.05)

0% (ns)

Etanercept 1.0 mg/kg

76% (P < 0.001)

52% (P < 0.001)

24% (ns)

0% (ns)

Dexamethasone

nd

84% (P < 0.001)

nd

39% (P < 0.05)

  1. *The values of statistical significance against SCW vehicle groups are represented in parenthesis. In all cases, non-arthritic controls were significantly different from SCW vehicle groups (P < 0.001). Values are calculated from 8–11 rats per group. ns: not significant; nd: not determined.