Figure 5
Induction of an additional flare (flare 3): evaluation of inflammation and pain. (A) Inflammation of the ankle joint following intra-articular sensitization (day 1; flare 1), the first intravenous challenge (day 21; flare 2) and the second intravenous challenge (day 42; flare 3). (B) Mechanical pain response (withdrawal threshold) in the same rats over the same time period. Values are mean ± SEM of n =8 rats per group.