Skip to main content

Table 3 Meta-analysis of GDF5 rs143383 polymorphism and knee OA

From: Association between GDF5 rs143383 polymorphism and knee osteoarthritis: an updated meta-analysis based on 23,995 subjects

Population

Comparison (Na)

Test of association

Test of heterogeneity

  

OR (95% CI)

P b

P c

I 2(%)

Overall

C vs. T (20)

0.85 (0.80-0.90)

0.000

0.019

44.1

 

CC vs. TT (17)

0.73 (0.66-0.81)

0.000

0.328

10.8

 

CT vs. TT (17)

0.84 (0.76-0.94)

0.002

0.000

62.2

 

CC/CT vs. TT (17)

0.81 (0.73-0.90)

0.000

0.000

61.7

 

CC vs. CT/TT (17)

0.81 (0.74-0.86)

0.000

0.623

0.0

Ethnicity

     

Asian

C vs. T (6)

0.78 (0.67-0.92)

0.003

0.006

69.5

 

CC vs. TT (6)

0.60 (0.48-0.76)

0.000

0.333

12.9

 

CT vs. TT (6)

0.80 (0.63-1.02)

0.071

0.002

74.3

 

CC/CT vs. TT (6)

0.76 (0.60-0.96)

0.021

0.001

75.8

 

CC vs. CT/TT (6)

0.68 (0.56-0.84)

0.000

0.494

0.0

Caucasian

C vs. T (14)

0.87 (0.82-0.92)

0.000

0.229

20.7

 

CC vs. TT (11)

0.78 (0.70-0.87)

0.000

0.611

0.0

 

CT vs. TT (11)

0.86 (0.76-0.97)

0.012

0.011

56.2

 

CC/CT vs. TT (11)

0.83 (0.75-0.93)

0.001

0.020

52.6

 

CC vs. CT/TT (11)

0.84 (0.76-0.93)

0.001

0.822

0.0

Sex

     

Females

C vs. T (9)

0.85 (0.78-0.93)

0.000

0.236

23.3

 

CC vs. TT (9)

0.73 (0.62-0.87)

0.000

0.923

0.0

 

CT vs. TT (9)

0.81 (0.69-0.95)

0.011

0.029

53.2

 

CC/CT vs. TT (9)

0.80 (0.69-0.93)

0.003

0.039

50.7

 

CC vs. CT/TT (9)

0.83 (0.70-0.97)

0.021

0.990

0.0

Males

C vs. T (9)

0.85 (0.74-0.97)

0.020

0.171

30.9

 

CC vs. TT (9)

0.65 (0.50-0.84)

0.001

0.464

0.0

 

CT vs. TT (9)

0.99 (0.81-1.20)

0.888

0.139

34.8

 

CC/CT vs. TT (9)

0.90 (0.74-1.09)

0.272

0.107

39.1

 

CC vs. CT/TT (9)

0.66 (0.51-0.84)

0.001

0.613

0.0

  1. OR odds ratio, CI confidence interval, aNumber of comparison, b P values for within group differences were determined by Z test, c P P value of Q-test for heterogeneity test.