Association between GDF5 rs143383 polymorphism and knee osteoarthritis: an updated meta-analysis based on 23,995 subjects

Table 2 Distributions of GDF5 rs143383 genotypes and alleles among cases and controls

First author	Year	Case			Control			Case		Control		P ^HWE
		TT	TC	CC	TT	TC	CC	T	C	T	C
Southam^a	2007	141	168	40	324	372	126	450	248	1020	624	0.262
Southam^b	2007	102	136	36	439	563	194	340	208	1441	951	0.550
Miyamoto^a	2007	444	243	31	473	330	58	1131	305	1276	446	0.966
Miyamoto^b	2007	197	97	19	244	193	48	491	135	681	289	0.283
Tsezou	2007	95	126	30	99	125	44	316	186	323	213	0.669
Chapman	2008	54	72	16	289	331	104	180	104	909	539	0.558
Valdes^a	2009	337	313	85	238	329	79	987	483	805	487	0.032
Valdes^b	2009	126	98	35	181	244	84	350	168	606	412	0.908
Vaes	2009	276	298	93	752	1014	331	850	484	2518	1617	0.724
Evangelou^a	2009	535	379	157	552	442	175	1449	693	1546	792	0.000
Evangelou^b	2009	NA	NA	NA	NA	NA	NA	230	124	679	417	NA
Evangelou^c	2009	NA	NA	NA	NA	NA	NA	124	94	251	167	NA
Cao	2010	150	115	11	159	113	26	415	137	431	165	0.360
Tawonsawatruk	2011	38	41	11	33	47	23	117	63	113	93	0.424
Valdes^a	2011	413	361	93	294	354	110	1187	547	942	574	0.837
Valdes^b	2011	32	24	9	168	179	80	88	42	515	339	0.010
Valdes^c	2011	467	511	163	219	237	80	1445	837	675	397	0.229
Valdes^d	2011	NA	NA	NA	NA	NA	NA	195	107	1930	1234	NA
Shin	2012	382	305	38	942	689	106	1069	381	2573	901	0.176
Mhishra	2013	124	130	46	84	160	56	378	222	328	272	0.188

^a,b,c and ^dDenote an independent study in the one article, respectively; HWE Hardy-Weinberg equilibrium; NA Data not available.

ISSN: 1471-2474