Analysis of association of MEF2C, SOST and JAG1 genes with bone mineral density in Mexican-Mestizo postmenopausal women

Table 3 Genotype/allele frequencies and Hardy-Weinberg equilibrium (HWE) P values for the analyzed SNPs

^aSNP reference number	Genotype	N	%	^bHWE
rs1366594 *MEF2C*	C/C	186	46.6	p = 0.30
	C/A	166	41.6
	A/A	47	11.8
Allele frequency	C	538	67.4
Allele frequency	A	260	32.6
rs9911277 *SOST*	G/G	113	28.6	p = 0.70
	G/A	193	48.9
	A/A	89	22.5
Allele frequency	G	419	53.0
Allele frequency	A	371	47.0
rs4793018 *SOST*	C/C	117	29.5	p = 0.58
	C/T	192	48.4
	T/T	88	22.2
Allele frequency	C	426	53.7
Allele frequency	T	368	46.3
rs1983490 *SOST*	G/G	121	30.3	p = 0.55
	G/A	192	48.1
	A/A	86	21.6
Allele frequency	G	434	54.4
Allele frequency	A	364	45.6
rs1881107 *SOST*	A/A	122	30.7	p = 0.43
	A/G	189	47.6
	G/G	86	21.7
Allele frequency	A	433	54.5
Allele frequency	G	361	45.5
rs4792909 *SOST*	G/G	116	29.2	p = 0.27
	G/T	187	47.1
	T/T	94	23.7
Allele frequency	G	419	52.8
Allele frequency	T	375	47.2
rs2273061 *JAG1*	A/A	132	33.2	p = 0.43
	A/G	201	50.5
	G/G	65	16.3
Allele frequency	A	465	58.4
Allele frequency	G	331	41.6
rs6040061 *JAG1*	A/A	147	37.1	p = 0.21
	A/C	198	50.0
	C/C	51	12.9
Allele frequency	A	492	62.1
Allele frequency	C	300	37.9
rs2235811 *JAG1*	C/C	151	38.1	p = 0.43
	C/T	193	48.7
	T/T	52	13.1
Allele frequency	C	495	62.5
Allele frequency	T	297	37.5

^a SNP = single nucleotide polymorphism; ^b HWE = Hardy-Weinberg Equilibrium.

ISSN: 1471-2474