TY - JOUR AU - Huisman, Elise AU - Lu, Alex AU - McCormack, Robert G. AU - Scott, Alex PY - 2014 DA - 2014/11/21 TI - Enhanced collagen type I synthesis by human tenocytes subjected to periodic in vitro mechanical stimulation JO - BMC Musculoskeletal Disorders SP - 386 VL - 15 IS - 1 AB - Mechanical stimulation (e.g. slow heavy loading) has proven beneficial in the rehabilitation of chronic tendinopathy, however the optimal parameters of stimulation have not been experimentally determined. In this study of mechanically stimulated human tenocytes, the influence of rest insertion and cycle number on (1) the protein and mRNA levels of type I and III collagen; (2) the mRNA levels of transforming growth factor beta (TGFB1) and scleraxis (SCXA); and (3) tenocyte morphology, were assessed. SN - 1471-2474 UR - https://doi.org/10.1186/1471-2474-15-386 DO - 10.1186/1471-2474-15-386 ID - Huisman2014 ER -