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Table 2 Results of quantitative synthesis involved the association between MMP-3 5A/6A polymorphisms and RA

From: Lack of association of matrix metalloproteinase-3 gene polymorphism with susceptibility to rheumatoid arthritis: a meta-analysis

Comparison model Overall Caucasians
Sample size (case/control) OR (95% CI) P h P P r Sample size (case/control) OR (95% CI) P h P
6A vs 5A 2902/2478 1.19(0.91-1.56)* 0.001 0.203 0.461 2340/2176 1.23(0.89-1.68)* 0.000 0.207
5A/6A vs 5A/5A 257/275 1.31(0.89-1.92) 0.106 0.174 0.824 200/243 1.37(0.68-2.76)* 0.058 0.373
6A/6A vs 5A/5A 401/292 1.78(0.68-4.61)* 0.003 0.238 0.835 169/169 2.11(0.66-6.67)* 0.002 0.209
Dominant model 593/477 1.46(0.71-3.00)* 0.015 0.299 0.766 312/326 1.61(0.68-3.80)* 0.008 0.274
Recessive model 593/477 1.48(0.88-2.47)* 0.023 0.141 0.257 312/326 1.69(0.84-3.40)* 0.021 0.142
  1. Dominant model: 6A/6A +5A/6A versus 5A/5A, Recessive model: 6A/6A versus 5A/5A +5A/6A, OR: odds ratio, CI: confidence interval, Ph: P -value of Q-test for heterogeneity test, P: P -value of Z-test for significance of the pooled OR, Pr: P -value of Egger's regression test for publication bias, *Significant heterogeneity: the random-effect model was chosen to summarize the result.