Pelubiprofen (n =77) | Celecoxib (n =68) | ||||
---|---|---|---|---|---|
Patients, n (%) | Events, n | Patients, n (%) | Events, n | p-value* | |
Total number of patients | 24 (31.2) | 34 | 14 (20.6) | 17 | 0.15 |
Gastrointestinal | 16 (20.8) | 20 | 6 (8.8) | 6 | 0.045 |
Anorexia | 2 (2.6) | 2 | 1 (1.47) | 1 | |
Nausea | 1 (1.3) | 2 | 2 (2.94) | 2 | |
Indigestion | 2 (2.6) | 2 | 1 (1.47) | 1 | |
Epigastric discomfort | 2 (2.6) | 2 | 0 (0.0) | 0 | |
Abdominal pain | 9 (11.7) | 9 | 2 (2.94) | 2 | |
Diarrhea | 1 (1.3) | 1 | 0 (0.0) | 0 | |
Constipation | 2 (2.6) | 2 | 0 (0.0) | 0 | |
Systemic | 8 (10.4) | 10 | 3 (4.4) | 3 | 0.17 |
Facial edema | 5 (6.49) | 5 | 1 (1.5) | 1 | |
Edema | 3 (3.9) | 4 | 1 (1.5) | 1 | |
Weight gain | 0 (0.0) | 0 | 1 (1.5) | 1 | |
Pain | 1 (1.3) | 1 | 0 (0.0) | 0 | |
Respiratory | 2 (2.6) | 2 | 1 (1.5) | 1 | 0.63 |
Nervous system | 0 (0.0) | 0 | 1 (1.5) | 1 | 0.29 |
Skin and appendage | 0 (0.0) | 0 | 1 (1.5) | 1 | 0.29 |
Hepatobiliary | 1 (1.3) | 1 | 1 (1.5) | 2 | 0.49 |
Reproductive system | 1 (1.3) | 1 | 0 (0.0) | 0 | 0.35 |
Cardiovascular | 0 (0.0) | 0 | 1 (1.5) | 1 | 0.29 |
Infection | 0 (0.0) | 0 | 1 (1.5) | 1 | 0.29 |
Peripheral vascular | 0 (0.0) | 0 | 1 (1.5) | 1 | 0.29 |