Figure 7

Effects of PAM treatment on OPG and RANKL protein expression and OPG/RANKL ratio in cartilage and subchondral bone. Relative levels measured by western-blotting are shown, (a) OPG protein expression in cartilage, (b) OPG protein expression in subchondral bone, (c) RANKL protein expression in cartilage, (d) RANKL protein expression in subchondral bone, (e) Ratio of OPG/RANKL in cartilage, (f) Ratio of OPG/RANKL in subchondral bone. * and ** indicate groups significantly different from the sham-operated rabbits treated with vehicle (*P <0.05 and **P <0.01). # and ## indicate significant differences between the ACLT group and rabbits treated with pamidronate. (# P <0.05 and ## P <0.01).