Quantitative analyses of the subchondral bone morphometric parameters from Micro-CT. Bone parameters assessed included (a) BV/TV, (b) DA, (c) SMI, (d) TbPf, (e) TbSp, (f) TbTh, (g) TbN. * and ** indicate groups significantly different from the sham-operated rabbits treated with vehicle (*P <0.05 and ** P <0.01). # and ## indicate significant differences between the ACLT group and rabbits treated with pamidronate. (# P <0.05 and ##: P <0.01).