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Table 3 Sensitivity, specificity, positive and negative predictive values and corresponding cut-offs of lumbar spine and femoral neck T-scores and FRAX major fracture model without BMD for the prediction of grade 2/3 vertebral fractures

From: The discriminative ability of FRAX, the WHO algorithm, to identify women with prevalent asymptomatic vertebral fractures: a cross-sectional study

FRAX major fractures without BMD Lumbar spine T-score Femoral neck T-score
Cut-off Se Sp PPV NPV PLR Cut-off Se Sp PPV NPV PLR Cut-off Se Sp PPV NPV PLR
≥1% 99.4 13.4 21.8 98.9 1,15 ≤-1 82.8 35.2 23.7 89.4 1,28 ≤-1 81.0 45.5 26.5 90.8 1,49
≥2% 84.7 51.6 29.8 93.3 1,75 ≤-2 57.7 61.3 26.6 85.6 1,49 ≤-2 46.0 80.3 36.2 86.0 2,34
≥3% 57.1 78.7 39.4 88.3 2,68 ≤-2.5 47.2 76.9 33.2 85.7 2,04 ≤-2.5 27.6 91.2 43.3 83.8 3,14
≥4% 34.4 88.8 42.7 84.8 3,07 ≤-3 32.5 88.5 40.8 84.4 2,83 ≤-3 13.5 96.9 51.2 82.2 4,35
  1. Se: sensitivity, Sp: specificity, PPV: positive predictive value, NPV: negative predictive value, PLR: positive likelihood ratio.