The discriminative ability of FRAX, the WHO algorithm, to identify women with prevalent asymptomatic vertebral fractures: a cross-sectional study

Table 3 Sensitivity, specificity, positive and negative predictive values and corresponding cut-offs of lumbar spine and femoral neck T-scores and FRAX major fracture model without BMD for the prediction of grade 2/3 vertebral fractures

FRAX major fractures without BMD						Lumbar spine T-score						Femoral neck T-score
Cut-off	Se	Sp	PPV	NPV	PLR	Cut-off	Se	Sp	PPV	NPV	PLR	Cut-off	Se	Sp	PPV	NPV	PLR
≥1%	99.4	13.4	21.8	98.9	1,15	≤-1	82.8	35.2	23.7	89.4	1,28	≤-1	81.0	45.5	26.5	90.8	1,49
≥2%	84.7	51.6	29.8	93.3	1,75	≤-2	57.7	61.3	26.6	85.6	1,49	≤-2	46.0	80.3	36.2	86.0	2,34
≥3%	57.1	78.7	39.4	88.3	2,68	≤-2.5	47.2	76.9	33.2	85.7	2,04	≤-2.5	27.6	91.2	43.3	83.8	3,14
≥4%	34.4	88.8	42.7	84.8	3,07	≤-3	32.5	88.5	40.8	84.4	2,83	≤-3	13.5	96.9	51.2	82.2	4,35

Se: sensitivity, Sp: specificity, PPV: positive predictive value, NPV: negative predictive value, PLR: positive likelihood ratio.

ISSN: 1471-2474