Girls | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|
Baseline | Between-group differences baseline | Annual changes | Between-group differences annual changes | |||||||
Cases (n = 47) | Controls (n = 46) | Adjusted difference (95% CI) | P1-value | P2-value | Cases (n = 47) | Controls (n = 46) | Adjusted difference (95% CI) | P3-value | P4-value | |
Anthropometry (kg) | ||||||||||
Height (cm) | 128.0 (5.2) | 129.9 (7.9) | -0.5 (-2.8, 1.9) | 0.18 | 0.70 | 6.2 (5.9, 6.5) | 6.0 (5.7, 6.3) | 0.3 (-0.1, 0.03) | 0.48 | 0.09 |
Weight (kg) | 27.6 (5.5) | 27.8 (5.6) | -0.2 (-2.1, 2.5) | 0.90 | 0.84 | 4.1 (3.6, 4.5) | 3.5 (3.1, 3.9) | 0.4 (-0.01, 0.8) | 0.04 | 0.05 |
BMI (kg/m2) | 16.8 (3.0) | 16.3 (1.9) | 0.4 (-0.7, 1.4) | 0.35 | 0.48 | 0.6 (0.4, 0.7) | 0.4 (0.2, 0.5) | 0.2 (0.01, 0.3) | 0.02 | 0.04 |
Lean body mass (kg) | ||||||||||
Total Body | 19.8 (2.3) | 20.4 (2.8) | -0.2 (-1.2, 0.8) | 0.25 | 0.66 | 2.4 (2.2, 2.6) | 2.3 (2.1, 2.5) | 0.1 (-0.03, 0.3) | 0.37 | 0.12 |
Legs | 6.3 (1.0) | 6.4 (1.2) | -0.03 (0.4, 0.5) | 0.55 | 0.87 | 1.0 (0.9, 1.1) | 1.0 (0.9, 1.0) | 0.04 (-0.03, 0.1) | 0.37 | 0.24 |
Arms | 1.6 (0.3) | 1.7 (0.4) | -0.1 (-0.2, 0.1) | 0.10 | 0.20 | 0.3 (0.2, 0.3) | 0.2 (0.2, 0.2) | 0.04 (-0.01, 0.1) | 0.10 | 0.01 |
Fat mass (kg) | ||||||||||
Total Body | 4.8 (3.1) | 5.0 (3.1) | 0.2 (-1.5, 1.1) | 0.76 | 0.76 | 1.6 (1.3, 1.9) | 1.0 (0.7, 1.2) | 0.5 (0.2, 0.9) | 0.003 | 0.001 |
Legs | 2.1 (1.1) | 2.2 (1.2) | 0.1 (-0.6, 0.4) | 0.70 | 0.73 | 0.6 (0.5, 0.7) | 0.4 (0.3, 0.5) | 0.2 (0.1, 0.3) | 0.02 | 0.002 |
Arms | 0.5 (0.4) | 0.5 (0.4) | -0.04 (-0.2, 0.1) | 0.68 | 0.66 | 0.1 (0.1, 0.2) | 0.1 (0.03, 0.1) | 0.1 (0.02, 0.1) | <0.001 | 0.03 |
Peak torque (Nm) | ||||||||||
PTEx60 | 40.9 (9.7) | 44.4 (9.8) | -1.6 (-5.2, 1.9) | 0.09 | 0.36 | 10.5 (9.3, 11.8) | 10.8 (9.7, 12.0) | -0.6 (-2.1, 0.8) | 0.75 | 0.40 |
PTFl60 | 19.6 (5.1) | 24.4 (6.2) | -4.1 (-6.4, -1.9) | <0.001 | <0.001 | 6.3 (5.7, 7.0) | 5.2 (4.6, 5.9) | 1.0 (0.1, 1.9) | 0.02 | 0.03 |
PTEx180 | 31.9 (7.9) | 36.1 (7.4) | -2.8 (-5.7, 0.1) | 0.01 | 0.06 | 7.4 (6.6, 8.2) | 7.1 (6.4, 7.7) | 0.3 (-0.6, 1.2) | 0.54 | 0.57 |
PTFl180 | 16.9 (5.5) | 22.1 (4.6) | -4.5 (-6.5, -2.5) | <0.001 | <0.001 | 4.8 (4.2, 5.4) | 4.1 (3.4, 4.7) | 0.4 (0.5, 1.4) | 0.10 | 0.35 |
Relative peak torque (Nm/Kg) | ||||||||||
PTEx60 | 1.5 (0.3) | 1.7 (0.3) | -0.1 (-0.2, 0.03) | 0.03 | 0.13 | 0.1 (0.1, 0.2) | 0.1 (0.1, 0.2) | -3.4 (-6.9, 0.2) | 0.26 | 0.06 |
PTFl60 | 0.7 (0.2) | 0.9 (0.1) | -0.2 (-0.2, -0.1) | <0.001 | <0.001 | 0.1 (0.1, 0.1) | 0.1 (0.04, 0.1) | 1.5 (-1.3, 4.3) | 0.08 | 0.30 |
PTEx180 | 1.2 (0.2) | 1.3 (0.2) | -0.1 (-0.2. -0.03) | 0.001 | <0.01 | 0.1 (0.1, 0.1) | 0.1 (0.1, 0.1) | -1.0 (-3.2, 1.3) | 0.91 | 0.41 |
PTFl180 | 0.6 (0.2) | 0.8 (0.1) | -0.1 (-0.2, -0.1) | <0.001 | <0.001 | 0.1 (0.04, 0.1) | 0.03 (0.02, 0.1) | -1.0 (-3.4, 1.5) | 0.048 | 0.44 |
Boys | ||||||||||
Baseline | Between-group differences baseline | Annual changes | Between-group differences annual changes | |||||||
Cases (n = 76) | Controls (n = 54) | Adjusted difference (95% CI) | P 1 -Value | P 2 -Value | Cases (n = 76) | Controls (n = 54) | Adjusted difference (95% CI) | P 3 -Value | P 4 -Value | |
Anthropometry (kg) | ||||||||||
Height (cm) | 129.4 (6.6) | 130.0 (6.8) | -0.2 (-1.8, 2.2) | 0.62 | 0.83 | 5.5 (5.3, 5.6) | 5.6 (5.4, 5.8) | 0.1 (-0.2, 0.4) | 0.32 | 0.53 |
Weight (kg) | 28.4 (5.8) | 27.8 (5.6) | 1.2 (-0.6, 3.0) | 0.54 | 0.20 | 3.5 (3.2, 3.8) | 3.6 (3.3, 3.9) | -0.004 (-0.5, 0.4) | 0.71 | 0.88 |
BMI (kg/m2) | 16.8 (2.5) | 16.3 (2.1) | 0.7 (-0.1, 1.5) | 0.21 | 0.11 | 0.4 (0.3, 0.5) | 0.5 (0.4, 0.6) | -0.1 (-0.3, 0.1) | 0.30 | 0.32 |
Lean body mass (kg) | ||||||||||
Total Body | 21.8 (3.1) | 21.6 (2.9) | 0.5 (-0.4, 1.4) | 0.72 | 0.27 | 2.2 (2.1, 2.3) | 2.3 (2.2, 2.4) | -0.1 (-0.2, 0.1) | 0.28 | 0.60 |
Legs | 6.8 (1.3) | 6.8 (1.3) | 0.2 (-0.2, 0.6) | 0.81 | 0.27 | 1.0 (0.9, 1.0) | 1.1 (1.0, 1.1) | -0.1 (-0.1, -0.02) | 0.05 | 0.16 |
Arms | 1.8 (0.4) | 1.8 (0.4) | 0.04 (-0.1, 0.2) | 0.90 | 0.47 | 0.3 (0.2, 0.3) | 0.2 (0.2, 0.2) | 0.03 (-0.004, 0.1) | 0.16 | 0.08 |
Fat mass (kg) | ||||||||||
Total Body | 3.8 (3.0) | 3.7 (2.6) | 0.3 (-0.7, 1.3) | 0.81 | 0.56 | 1.1 (0.9, 1.4) | 1.1 (0.8, 1.3) | 0.1 (-0.2, 0.4) | 0.62 | 0.57 |
Legs | 1.7 (1.1) | 1.6 (0.9) | 0.1 (-0.2, 0.5) | 0.66 | 0.40 | 0.5 (0.4, 0.6) | 0.4 (0.4, 0.5) | 0.01 (-0.1, 0.1) | 0.64 | 0.90 |
Arms | 0.3 (0.3) | 0.4 (0.4) | 0.1 (-0.2, 0.1) | 0.27 | 0.41 | 0.1 (0.1, 0.1)) | 0.1 (0.03, 0.1) | 0.03 (-0.01, 0.1) | 0.03 | 0.11 |
Peak torque (Nm) | ||||||||||
PTEx60 | 43.9 (11.0) | 44.6 (10.9) | 0.6 (-2.5, 3.7) | 0.71 | 0.70 | 9.8 (8.8, 10.7) | 10.8 (9.6, 12.0) | -0.8 (-2.5, 0.9) | 0.17 | 0.36 |
PTFl60 | 21.8 (6.7) | 25.0 (6.7) | -2.4 (-4.5, -0.4) | 0.01 | 0.02 | 7.1 (6.6, 7.7) | 5.9 (5.3, 6.5) | 1.9 (0.9, 2.9) | 0.005 | <0.001 |
PTEx180 | 35.9 (8.3) | 35.8 (7.5) | 1.1 (-1.1, 3.3) | 0.90 | 0.34 | 7.0 (6.5, 7.5) | 7.6 (7.0, 8.3) | -0.4 (-1.3, 0.5) | 0.15 | 0.42 |
PTFl180 | 19.3 (5.5) | 23.0 (5.1) | -3.2 (-4.9, -1.6) | <0.001 | <0.001 | 5.6 (5.1, 6.1) | 4.3 (3.8, 4.8) | 1.5 (0.5, 2.5) | 0.001 | 0.004 |
Relative peak torque (Nm/Kg) | ||||||||||
PTEx60 | 1.6 (0.2) | 1.7 (0.3) | -0.1 (-0.2, 0.01) | <0.05 | 0.10 | 0.1 (0.1, 0.1) | 0.1 (0.1, 0.2) | -0.5 (-4.6, 3.6) | 0.82 | 0.80 |
PTFl60 | 0.8 (0.2) | 0.9 (0.2) | -0.1 (-0.2, -0.1) | <0.001 | <0.001 | 0.1 (0.1, 0.1) | 0.1 (0.06, 0.1) | 3.2 (0.6, 5.8) | <0.001 | 0.02 |
PTEx180 | 1.3 (0.2) | 1.3 (0.2) | -0.1 (-0.1, 0.02) | 0.07 | 0.15 | 0.1 (0.1, 0.1) | 0.1 (0.1, 0.01) | 0.8 (-3.2, 1.6) | 0.62 | 0.51 |
PTFl180 | 0.7 (0.2) | 0.9 (0.1) | -0.2 (-0.2, -0.1) | <0.001 | <0.001 | 0.1 (0.1, 0.1) | 0.03 (0.03, 0.1) | 3.1 (0.7, 5.5) | <0.001 | 0.01 |