Influence of 1,25(OH)
therapy on parameters of bone formation measured by tetracylin labeling (secondary spongiosa of the right tibia head – arthritic joint) in AIA of the rat. Mineralizing surface (A), mineral apposition rate (B) and bone formation rate (C) were unaffected by AIA. Treatment with 1,25(OH)2D3 resulted in a highly significant increase of mineral apposition rate and bone formation rate and a significant increase in mineralizing surface compared with vehicle-treated AIA and healthy controls. ***p < 0.001; *p < 0.05 vs. AIA + vehicle; +++p < 0.001; ++p < 0.01 vs. healthy controls.