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Figure 2 | BMC Musculoskeletal Disorders

Figure 2

From: Monosodium urate crystal induced macrophage inflammation is attenuated by chondroitin sulphate: pre-clinical model for gout prophylaxis?

Figure 2

The origin of IL-1β from MSU stimulated macrophages was consistent with NLRP3 inflammasome activation. THP-1 macrophages were pretreated for 6 hours with varying concentrations of a Caspase-1 inhibitor (range 0–10 μM) followed by stimulation with MSU (20 mg/dl) for 24 hours. In response to the Caspase-1 inhibitor, IL-1β was reduced in a dose-deoendent manner to the level produced by THP-1 in the absence of MSU (far right three bars). Results are expressed as a percent of the positive control—MSU in the absence of Caspase-1 (first bar on left).

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