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Figure 1 | BMC Musculoskeletal Disorders

Figure 1

From: Monosodium urate crystal induced macrophage inflammation is attenuated by chondroitin sulphate: pre-clinical model for gout prophylaxis?

Figure 1

Exposure of macrophages to high physiological concentrations of monosodium urate (MSU) crystals stimulated IL-1β production. THP-1 macrophages were exposed to MSU crystals of varying concentrations (range 0–20 mg/dl) for 24 hours. MSU concentrations of ≥ 10 mg/dl consistently induced IL-1β production as shown here in this representative experiment; this prompted us to choose 10–20 mg/dl for all subsequent experiments. Results are expressed as a percent of the negative control (left bar with no MSU).

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