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Table 4 Interaction of the TNFα SNPs with the IL4R and IL10 SNPs in their effect on hand OA

From: Variations in the TNFα gene and their interactions with the IL4R and IL10 genes in relation to hand osteoarthritis

   n OR 95% CI p-value
IL4R TNFα “-1031”     0.01
Ser/Ser T/T 67/270 1.00   
  T/C – C/C 52/138 2.01 1.26-3.22  
Ser/Pro-Pro/Pro T/T 33/94 1.00   
  T/C – C/C 8/39 0.55 0.22-1.40  
IL4R TNFα “-863    0.05
Ser/Ser C/C 71/285 1.00   
  C/A – A/A 33/99 2.09 1.29-3.27  
Ser/Pro-Pro/Pro C/C 48/123 1.00   
  C/A – A/A 8/34 0.72 0.28-1.87  
IL10 TNFα “-1031”     0.007
G/A T/T 55/175 1.00   
  T/C – C/C 20/83 0.80 0.43-1.51  
A/A-G/G T/T 29/120 1.00   
  T/C – C/C 27/66 2.54 1.45-4.47  
IL10 TNFα “-863    0.02
G/A C/C 56/186 1.00   
  C/A – A/A 19/72 0.94 0.49-1.80  
A/A-G/G C/C 48/198 1.00   
  C/A – A/A 37/85 2.60 1.46-4.62  
  1. Odds ratios (ORs) and 95% confidence intervals (CIs) are adjusted for age, occupation and body mass index (BMI).
  2. SNP single nucleotide polymorphism, OA osteoarthritis, OR odds ratio, CI confidence interval.