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Table 3 Association of the variants in the cytokine genes with hand OA

From: Variations in the TNFα gene and their interactions with the IL4R and IL10 genes in relation to hand osteoarthritis

   

Hand OA n = 160 (542)

Genes

Localization

SNP ID

OR (95% CI)1

p-value

OR (95% CI)2

p-value

TNFα

−1031

rs1799964

1.45 (1.01-2.07)

0.04

1.47 (1.02-2.13)

0.03

TNFα

−863

rs1800630

1.55 (1.06-2.25)

0.02

1.61 (1.10-2.36)

0.01

TNFα

−857

rs1799724

0.77 (0.44-1.35)

0.35

0.77 (0.44-1.35)

0.36

TNFα

−308

rs1800629

1.25 (0.83-1.86)

0.29

1.19 (0.79-1.79)

0.39

IL4R

Ser752Ala

rs1805016

1.41 (0.67-2.99)

0.37

1.47 (0.69-2.32)

0.33

IL4R

Ser503Pro

rs1805015

1.17 (0.77-1.77)

0.47

1.17 (0.76-1.78)

0.48

IL10

−1082

rs1800896

0.96 (0.73-1.27)

0.80

0.95 (0.71-1.25)

0.70

IL1β

3954

rs1143634

1.39 (1.02-1.88)

0.03

  

IL6

174

rs1800795

1.21 (0.92-1.59)

0.18

  
  1. 1ORs and their 95% CIs were adjusted for age, occupation and BMI.
  2. 2ORs and their 95% CIs were adjusted for age, occupation, BMI and carriage of the minor allele of the IL1β (rs1143634) or/and IL6 (rs1800795) SNPs.
  3. OA osteoarthritis, SNP single nucleotide polymorphism, OR odds ratio, CI confidence interval, BMI body mass index.
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BMC Musculoskeletal Disorders

ISSN: 1471-2474

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