| | |
Hand OA n = 160 (542)
|
---|
Genes
|
Localization
|
SNP ID
|
OR (95% CI)1
|
p-value
|
OR (95% CI)2
|
p-value
|
---|
TNFα
|
−1031
|
rs1799964
|
1.45 (1.01-2.07)
|
0.04
|
1.47 (1.02-2.13)
|
0.03
|
TNFα
|
−863
|
rs1800630
|
1.55 (1.06-2.25)
|
0.02
|
1.61 (1.10-2.36)
|
0.01
|
TNFα
|
−857
|
rs1799724
|
0.77 (0.44-1.35)
|
0.35
|
0.77 (0.44-1.35)
|
0.36
|
TNFα
|
−308
|
rs1800629
|
1.25 (0.83-1.86)
|
0.29
|
1.19 (0.79-1.79)
|
0.39
|
IL4R
|
Ser752Ala
|
rs1805016
|
1.41 (0.67-2.99)
|
0.37
|
1.47 (0.69-2.32)
|
0.33
|
IL4R
|
Ser503Pro
|
rs1805015
|
1.17 (0.77-1.77)
|
0.47
|
1.17 (0.76-1.78)
|
0.48
|
IL10
|
−1082
|
rs1800896
|
0.96 (0.73-1.27)
|
0.80
|
0.95 (0.71-1.25)
|
0.70
|
IL1β
|
3954
|
rs1143634
|
1.39 (1.02-1.88)
|
0.03
| | |
IL6
|
174
|
rs1800795
|
1.21 (0.92-1.59)
|
0.18
| | |
-
1ORs and their 95% CIs were adjusted for age, occupation and BMI.
-
2ORs and their 95% CIs were adjusted for age, occupation, BMI and carriage of the minor allele of the IL1β (rs1143634) or/and IL6 (rs1800795) SNPs.
-
OA osteoarthritis, SNP single nucleotide polymorphism, OR odds ratio, CI confidence interval, BMI body mass index.