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Table 3 Association of the variants in the cytokine genes with hand OA

From: Variations in the TNFα gene and their interactions with the IL4R and IL10 genes in relation to hand osteoarthritis

    Hand OA n = 160 (542)
Genes Localization SNP ID OR (95% CI)1 p-value OR (95% CI)2 p-value
TNFα −1031 rs1799964 1.45 (1.01-2.07) 0.04 1.47 (1.02-2.13) 0.03
TNFα −863 rs1800630 1.55 (1.06-2.25) 0.02 1.61 (1.10-2.36) 0.01
TNFα −857 rs1799724 0.77 (0.44-1.35) 0.35 0.77 (0.44-1.35) 0.36
TNFα −308 rs1800629 1.25 (0.83-1.86) 0.29 1.19 (0.79-1.79) 0.39
IL4R Ser752Ala rs1805016 1.41 (0.67-2.99) 0.37 1.47 (0.69-2.32) 0.33
IL4R Ser503Pro rs1805015 1.17 (0.77-1.77) 0.47 1.17 (0.76-1.78) 0.48
IL10 −1082 rs1800896 0.96 (0.73-1.27) 0.80 0.95 (0.71-1.25) 0.70
IL1β 3954 rs1143634 1.39 (1.02-1.88) 0.03   
IL6 174 rs1800795 1.21 (0.92-1.59) 0.18   
  1. 1ORs and their 95% CIs were adjusted for age, occupation and BMI.
  2. 2ORs and their 95% CIs were adjusted for age, occupation, BMI and carriage of the minor allele of the IL1β (rs1143634) or/and IL6 (rs1800795) SNPs.
  3. OA osteoarthritis, SNP single nucleotide polymorphism, OR odds ratio, CI confidence interval, BMI body mass index.