|
Genes
|
Localization
|
SNP ID
|
Chro.
|
Position
|
MAF
|
HWE
|
|---|
|
Total (n = 1084)
|
OA Cases (n = 320)
|
OA Controls (n = 764)
|
1000 Genomes Finland# (n = 186)
|
HapMap¤ (n = 226)
|
p-value in controls
|
|---|
|
%
|
n
|
%
|
n
|
%
|
n
|
%
|
n
|
%
|
n
|
|---|
|
TNFα
|
−1031
|
rs1799964
|
6
|
31542308
|
18
|
191
|
21
|
66
|
16
|
125
|
19
|
35
|
21
|
48
|
0.41
|
|
TNFα
|
−863
|
rs1800630
|
6
|
31542476
|
16
|
168
|
19
|
60
|
14
|
108
|
15
|
27
|
15
|
34
|
0.79
|
|
TNFα
|
−857
|
rs1799724
|
6
|
31542482
|
6.4
|
69
|
5.6
|
18
|
6.7
|
51
|
6.5
|
12
|
NA/5.9*
|
10
|
0.81
|
|
TNFα
|
−308
|
rs1800629
|
6
|
31543031
|
13
|
144
|
15
|
47
|
13
|
97
|
13
|
24
|
17
|
39
|
0.59
|
|
IL4R
|
Ser752Ala
|
rs1805016
|
16
|
27374927
|
3.2
|
35
|
4.1
|
13
|
2.9
|
22
|
5.4
|
10
|
6.3
|
14
|
0.56
|
|
IL4R
|
Ser503Pro
|
rs1805015
|
16
|
27374180
|
13
|
139
|
14
|
44
|
12
|
95
|
15
|
27
|
15
|
34
|
0.17
|
|
IL10
|
−1082
|
rs1800896
|
1
|
206946897
|
42
|
453
|
42
|
133
|
42
|
320
|
39
|
73
|
47
|
120
|
0.84
|
|
IL1β
|
3954
|
rs1143634
|
2
|
113590390
|
27
|
294
|
31
|
98
|
26
|
196
|
24
|
44
|
21
|
47
|
0.97
|
|
IL6
|
174
|
rs1800795
|
7
|
22766645
|
44
|
475
|
48
|
153
|
42
|
322
|
44
|
82
|
47
|
105
|
0.88
|
- #1000 genomes European sub-population, Finnish in Finland.
- ¤HapMap population is CEU: Utah residents with Northern and Western European ancestry from the CEPH collection.
- *1000 genomes, population is CEU: Utah residents (CEPH) with Northern and Western European ancestry, n = 170.
-
SNP single nucleotide polymorphism, MAF minor allele frequency, HWE Hardy-Weinberg equilibrium, OA osteoarthritis.
