Variations in the TNFα gene and their interactions with the IL4R and IL10 genes in relation to hand osteoarthritis

Table 2 Description of studied SNPs

Genes	Localization	SNP ID	Chro.	Position	MAF										HWE
					Total (n = 1084)		OA Cases (n = 320)		OA Controls (n = 764)		1000 Genomes Finland# (n = 186)		HapMap¤ (n = 226)		p-value in controls
					%	n	%	n	%	n	%	n	%	n	p-value in controls
TNFα	−1031	rs1799964	6	31542308	18	191	21	66	16	125	19	35	21	48	0.41
TNFα	−863	rs1800630	6	31542476	16	168	19	60	14	108	15	27	15	34	0.79
TNFα	−857	rs1799724	6	31542482	6.4	69	5.6	18	6.7	51	6.5	12	NA/5.9*	10	0.81
TNFα	−308	rs1800629	6	31543031	13	144	15	47	13	97	13	24	17	39	0.59
IL4R	Ser752Ala	rs1805016	16	27374927	3.2	35	4.1	13	2.9	22	5.4	10	6.3	14	0.56
IL4R	Ser503Pro	rs1805015	16	27374180	13	139	14	44	12	95	15	27	15	34	0.17
IL10	−1082	rs1800896	1	206946897	42	453	42	133	42	320	39	73	47	120	0.84
IL1β	3954	rs1143634	2	113590390	27	294	31	98	26	196	24	44	21	47	0.97
IL6	174	rs1800795	7	22766645	44	475	48	153	42	322	44	82	47	105	0.88

#1000 genomes European sub-population, Finnish in Finland.
¤HapMap population is CEU: Utah residents with Northern and Western European ancestry from the CEPH collection.
*1000 genomes, population is CEU: Utah residents (CEPH) with Northern and Western European ancestry, n = 170.
SNP single nucleotide polymorphism, MAF minor allele frequency, HWE Hardy-Weinberg equilibrium, OA osteoarthritis.

ISSN: 1471-2474