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Table 2 Description of studied SNPs

From: Variations in the TNFα gene and their interactions with the IL4R and IL10 genes in relation to hand osteoarthritis

Genes Localization SNP ID Chro. Position MAF HWE
Total (n = 1084) OA Cases (n = 320) OA Controls (n = 764) 1000 Genomes Finland# (n = 186) HapMap¤ (n = 226) p-value in controls
% n % n % n % n % n
TNFα −1031 rs1799964 6 31542308 18 191 21 66 16 125 19 35 21 48 0.41
TNFα −863 rs1800630 6 31542476 16 168 19 60 14 108 15 27 15 34 0.79
TNFα −857 rs1799724 6 31542482 6.4 69 5.6 18 6.7 51 6.5 12 NA/5.9* 10 0.81
TNFα −308 rs1800629 6 31543031 13 144 15 47 13 97 13 24 17 39 0.59
IL4R Ser752Ala rs1805016 16 27374927 3.2 35 4.1 13 2.9 22 5.4 10 6.3 14 0.56
IL4R Ser503Pro rs1805015 16 27374180 13 139 14 44 12 95 15 27 15 34 0.17
IL10 −1082 rs1800896 1 206946897 42 453 42 133 42 320 39 73 47 120 0.84
IL1β 3954 rs1143634 2 113590390 27 294 31 98 26 196 24 44 21 47 0.97
IL6 174 rs1800795 7 22766645 44 475 48 153 42 322 44 82 47 105 0.88
  1. #1000 genomes European sub-population, Finnish in Finland.
  2. ¤HapMap population is CEU: Utah residents with Northern and Western European ancestry from the CEPH collection.
  3. *1000 genomes, population is CEU: Utah residents (CEPH) with Northern and Western European ancestry, n = 170.
  4. SNP single nucleotide polymorphism, MAF minor allele frequency, HWE Hardy-Weinberg equilibrium, OA osteoarthritis.