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Table 3 Serum levels of 3 biomarkers in 271 samples divided by KL score

From: Type X collagen levels are elevated in serum from human osteoarthritis patients and associated with biomarkers of cartilage degradation and inflammation

KL scroe

Number of Female/male

Age

BMI

C-Col10

hsCRP μg/ml

C2M pg/ml

    

pg/ml

P value

  

0

4/6

62.5 (57.3-67.7)

25.4 (23.7-27.0)

52 (24–80)

n. a.

2.94 (−0.75-6.64)

287 (245–325)

1

31/28

63.7 (61.6-65.8)

27.0 (26.0-28.1)

65 (54–76)

0.11

2.12 (1.44-2.80)

299 (270–327)

2

79/65

64.7 (63.5-65.9)

28.2 (27.5-28.8)

86 (73–98)

0.04*

3.18 (2.26-4.10)

302 (283–321)

3

17/19

64.3 (61.9-66.7)

29.3 (27.4-31.2)

80 (60–101)

0.07

3.57 (1.35-5.79)

305 (264–346)

4

12/10

67.8 (64.4-71.2)

29.5 (27.8-31.2)

87 (47–128)

0.28

2.92 (1.90-3.94)

339 (271–406)

  1. The data is shown as mean [95-CI]. C-Col10: C-terminus of ColX assay; C2M: MMP-derived collagen type II fragment assay; hsCRP: high sensitive CRP assay. KL score: Kellgren-Lawrence score. One-way ANOVA was applied to compare the mean C-Col10 levels of each KL group with the mean of KL 0 group. P value was considered statistically significant if P < 0.05 and significant level was presented as: *.