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Table 3 Serum levels of 3 biomarkers in 271 samples divided by KL score

From: Type X collagen levels are elevated in serum from human osteoarthritis patients and associated with biomarkers of cartilage degradation and inflammation

KL scroe Number of Female/male Age BMI C-Col10 hsCRP μg/ml C2M pg/ml
     pg/ml P value   
0 4/6 62.5 (57.3-67.7) 25.4 (23.7-27.0) 52 (24–80) n. a. 2.94 (−0.75-6.64) 287 (245–325)
1 31/28 63.7 (61.6-65.8) 27.0 (26.0-28.1) 65 (54–76) 0.11 2.12 (1.44-2.80) 299 (270–327)
2 79/65 64.7 (63.5-65.9) 28.2 (27.5-28.8) 86 (73–98) 0.04* 3.18 (2.26-4.10) 302 (283–321)
3 17/19 64.3 (61.9-66.7) 29.3 (27.4-31.2) 80 (60–101) 0.07 3.57 (1.35-5.79) 305 (264–346)
4 12/10 67.8 (64.4-71.2) 29.5 (27.8-31.2) 87 (47–128) 0.28 2.92 (1.90-3.94) 339 (271–406)
  1. The data is shown as mean [95-CI]. C-Col10: C-terminus of ColX assay; C2M: MMP-derived collagen type II fragment assay; hsCRP: high sensitive CRP assay. KL score: Kellgren-Lawrence score. One-way ANOVA was applied to compare the mean C-Col10 levels of each KL group with the mean of KL 0 group. P value was considered statistically significant if P < 0.05 and significant level was presented as: *.