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Table 2 Summary of technical performance for 3 biomarkers assays

From: Type X collagen levels are elevated in serum from human osteoarthritis patients and associated with biomarkers of cartilage degradation and inflammation

 

C-Col10 (pg/ml)

hsCRP (μg/ml)

C2M (pg/ml)

Assay specifications

Slope of standard curve

1.23

n. a.

0.96

IC50, pg/ml

363

n. a.

440

Intra-assay CV%

4.19

n. a.

3.95

Inter-assay CV%

13.18

<5

9.88

Lower limit of detection

24

n. a.

n. a.

Quantifiable range

40-7300

0.2-10

30-1700

  1. C-Col10: C-terminus of ColX assay; C2M: MMP-derived collagen type II fragment assay; hsCRP: high sensitive CRP assay. n.a.: not available.