Table 3 List of metabolites identified by ¹ H-NMR analysis of serum samples from intact or immobilized mice after 7 days of treatment with GLPG0492 (10 mg/kg/d) or CTL

From: Characterization of GLPG0492, a selective androgen receptor modulator, in a mouse model of hindlimb immobilization

	Intact		Immobilized
	Mean	SEM	CTL			GLPG0492
			Mean	SEM	p-value	Mean	SEM	p-value
3-Hydroxybutyrate	239	46	184	25		1207	302	**
Acetate	542	92	460	6		857	124	*
Acetone	19	5	14	3		54		*
Alanine	1977	156	1214	191	##	1218	45
Asparagine	201	27	124	21	#	127	10
Betaine	142	32	79	32		114	14
Choline	222	24	189	24		251	34
Citrate	773	116	597	63		1076	169	*
Creatine	817	40	839	132		891	97
Dimethylamine	13	1	11	2		10	1
Ethanol	220	31	146	34		181	13
Formate	174	23	155	10		165	27
Fumarate	20	3	12	4		33	7	*
Glucose	29159	4531	23873	3222		33088	2902
Glutamate	337	37	256	37		334	27
Glutamine	1595	239	1019	125		1701	147	*
Glycerol	2638	238	2366	377		3010	469
Glycine	1400	138	893	130	#	1195	102
Histidine	248	27	169	32		218	17
Isobutyrate	57	10	30	4	#	49	6
Isoleucine	393	59	244	37		286	26
Lactate	19808	1196	13878	1491	#	16821	1797
Leucine	486	76	337	52		369	39
Lysine	744	49	792	100		737	81
Malonate	89	13	80	9		98	10
Mannose	106	15	136	28		251	35	*
Methionine	341	34	212	34	#	207	18
O-Acetylcarnitine	45	10	39	5		105	17	**
Phenylalanine	235	20	179	27		176	11
Proline	627	47	337	66	##	270	41
Pyruvate	480	23	261	32	#	471	65	*
Serine	740	67	449	64	##	524	29
Succinate	44	9	44	5		85	20
Taurine	2811	217	2860	452		3498	299
Threonine	938	85	636	117		631	34
Trimethylamine N-oxide	200	29	143	41		134	24
Tryptophan	83	7	65	8		52	11
Tyrosine	252	19	171	23	#	168	8
Urocanate	0	0	32	11	#	44	5
Valine	955	136	598	93		610

#p < 0.05, ##p < 0.01 immobilized vs. intact; *p < 0.05, **p < 0.01 GLPG0492-treated vs. CTL; Data are expressed as mean concentrations (μM) ± SEM.

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