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Table 3 List of metabolites identified by 1 H-NMR analysis of serum samples from intact or immobilized mice after 7 days of treatment with GLPG0492 (10 mg/kg/d) or CTL

From: Characterization of GLPG0492, a selective androgen receptor modulator, in a mouse model of hindlimb immobilization

  Intact Immobilized
Mean SEM CTL GLPG0492
    Mean SEM p-value Mean SEM p-value
3-Hydroxybutyrate 239 46 184 25   1207 302 **
Acetate 542 92 460 6   857 124 *
Acetone 19 5 14 3   54   *
Alanine 1977 156 1214 191 ## 1218 45  
Asparagine 201 27 124 21 # 127 10  
Betaine 142 32 79 32   114 14  
Choline 222 24 189 24   251 34  
Citrate 773 116 597 63   1076 169 *
Creatine 817 40 839 132   891 97  
Dimethylamine 13 1 11 2   10 1  
Ethanol 220 31 146 34   181 13  
Formate 174 23 155 10   165 27  
Fumarate 20 3 12 4   33 7 *
Glucose 29159 4531 23873 3222   33088 2902  
Glutamate 337 37 256 37   334 27  
Glutamine 1595 239 1019 125   1701 147 *
Glycerol 2638 238 2366 377   3010 469  
Glycine 1400 138 893 130 # 1195 102  
Histidine 248 27 169 32   218 17  
Isobutyrate 57 10 30 4 # 49 6  
Isoleucine 393 59 244 37   286 26  
Lactate 19808 1196 13878 1491 # 16821 1797  
Leucine 486 76 337 52   369 39  
Lysine 744 49 792 100   737 81  
Malonate 89 13 80 9   98 10  
Mannose 106 15 136 28   251 35 *
Methionine 341 34 212 34 # 207 18  
O-Acetylcarnitine 45 10 39 5   105 17 **
Phenylalanine 235 20 179 27   176 11  
Proline 627 47 337 66 ## 270 41  
Pyruvate 480 23 261 32 # 471 65 *
Serine 740 67 449 64 ## 524 29  
Succinate 44 9 44 5   85 20  
Taurine 2811 217 2860 452   3498 299  
Threonine 938 85 636 117   631 34  
Trimethylamine N-oxide 200 29 143 41   134 24  
Tryptophan 83 7 65 8   52 11  
Tyrosine 252 19 171 23 # 168 8  
Urocanate 0 0 32 11 # 44 5  
Valine 955 136 598 93   610   
  1. #p < 0.05, ##p < 0.01 immobilized vs. intact; *p < 0.05, **p < 0.01 GLPG0492-treated vs. CTL; Data are expressed as mean concentrations (μM) ± SEM.