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Table 2 Serum testosterone levels and body weight evolution in male mice treated for 7 days with increasing doses of GLPG0492 and TP

From: Characterization of GLPG0492, a selective androgen receptor modulator, in a mouse model of hindlimb immobilization

  Testosterone (nM) Body weight day 0 (gr) Body weight day 7 (gr) % BW increase (d7-d0)
Intact 2.4 ± 0.6 24.3 ± 0.3 25.5 ± 0.3 +5.0%
CTL 1.7 ± 0.3 24.2 ± 0.4 22.5 ± 0.5### -6.8%
GLPG0492 0.3 mg/kg/d 1.9 ± 0.6 24.2 ± 0.2 23.7 ± 0.3### -1.9%
GLPG0492 3 mg/kg/d 2.2 ± 0.8 23.6 ± 0.4 22.9 ± 0.3### -2.3%
GLPG0492 10 mg/kg/d 1.7 ± 0.6 23.8 ± 0.2 23.3 ± 0.3### -2.1%
TP 1 mg/kg/d 3.3 ± 0.5 23.8 ± 0.3 23.4 ± 0.4### -1.6%
  1. Data (n = 10 per group) are expressed as mean ± SEM. ###p < 0.001 vs. Intact (day7).