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Table 2 Serum testosterone levels and body weight evolution in male mice treated for 7 days with increasing doses of GLPG0492 and TP

From: Characterization of GLPG0492, a selective androgen receptor modulator, in a mouse model of hindlimb immobilization

 

Testosterone (nM)

Body weight day 0 (gr)

Body weight day 7 (gr)

% BW increase (d7-d0)

Intact

2.4 ± 0.6

24.3 ± 0.3

25.5 ± 0.3

+5.0%

CTL

1.7 ± 0.3

24.2 ± 0.4

22.5 ± 0.5###

-6.8%

GLPG0492 0.3 mg/kg/d

1.9 ± 0.6

24.2 ± 0.2

23.7 ± 0.3###

-1.9%

GLPG0492 3 mg/kg/d

2.2 ± 0.8

23.6 ± 0.4

22.9 ± 0.3###

-2.3%

GLPG0492 10 mg/kg/d

1.7 ± 0.6

23.8 ± 0.2

23.3 ± 0.3###

-2.1%

TP 1 mg/kg/d

3.3 ± 0.5

23.8 ± 0.3

23.4 ± 0.4###

-1.6%

  1. Data (n = 10 per group) are expressed as mean ± SEM. ###p < 0.001 vs. Intact (day7).
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BMC Musculoskeletal Disorders

ISSN: 1471-2474

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