Figure 3

GLPG0492 selectively modulated key pathways involved in muscle atrophy. Gene expression levels were monitored at day 7 in tibialis muscle samples from intact or immobilized mice receiving either GLPG0492 (10 mg/kg/day) or TP (1 mg/kg/day) or vehicle. Figure 3a: Atrogin-1, MurF1, LC3, IGFI, FoxO1 and Figure 3b: Myogenin, IL1B, PGC-1α (n = 10 per group; ##p < 0.01, ###p < 0.001 vs. Intact; *p < 0.05, **p < 0.01, ***p < 0.001 GLPG0492-treated vs. CTL immobilized).