Figure 1

GLPG0492 reversed immobilization-induced muscle atrophy in a dose-dependent manner. Normalized gastrocnemius weight from both immobilized (Panel A) and contralateral (Panel B) legs was assessed at day 7 in intact or immobilized mice receiving increasing doses of GLPG0492 (0.3, 3, 10 mg/kg/day) or TP (1 mg/kg/day) or CTL immobilized (ethanol/corn oil, 5/95 v/v). Panel C: Normalized prostate weight at day 7, from immobilized mice receiving increasing doses of GLPG0492 (0.3, 3, 10 mg/kg/day) or TP or CTL vehicle (n = 10 per group; #p < 0.05, ##p < 0.01, ###p < 0.001 vs. Intact (white bar); *p < 0.05, **p < 0.01, ***p < 0.001 vs. CTL immobilized (black bar)).