
Change in bone mineral density



Femoral neck

Total hip

Spine L14



02 yrs

210 yrs

02 yrs

210 yrs

02 yrs

210 yrs



Beta

Beta

Beta

Beta

Beta

Beta



p value

p value

p value

p value

p value

p value


Age (yrs)











B 0.244 P = 0.048

Women (N/Y)



B0.029 P = 0.027



B0.039 P = 0.004



B0.104 P = 0.000

Menopause (N/Y)



B0.033 P = 0.049

B 0.016 P = 0.076

B0.053 P = 0.003



B0.051 P = 0.063

Smoking (N/Y)



B0.028 p = 0.036



B0.024 P = 0.080





RF (N/Y)



B0.030 P = 0.030



B0.029 P = 0.047



B0.053 P = 0.044

MHAQ (0–3)

B −0.027 p = 0.034











ESR (mm/hr)









B0.189 P = 0.092
 
DAS28ESR3

B −0.010 P = 0.030

B0.015 P = 0.057



B0.016 P = 0.055

B0.013 P = 0.037



Ever use of biologic DMARDs (N/Y)

B0.023 P = 0.024



B0.019 P = 0.058



B0.023 P = 0.091

B0.052 P = 0.039

Cumulative equivalent prednisolon (gram)

B0.002 P = 0.024



B0.003 P = 0.003







 Variables are tested for their association with change in hip and spine bone density for the follow up periods 0–2 years and 2–10 years in early rheumatoid arthritis patients using univariate linear regression analysis. Unstandardized Beta values are only shown for variables with a p value ≤ 0.1.

Yrs: Years; N/Y: No/yes; RF: Rheumatoid factor; MHAQ: Modified health assessment questionnaire; ESR: Erythrocyte sedimentation rate; DAS28ESR3: Disease activity score based on 28 joint count (swollen and tender joints) and ESR; DMARDs: Disease modifying antirheumatic drugs.