Therapeutic effect of JWH133 on CIA. CIA mice were treated with intraperitoneal injection of JWH133 (4 mg/kg/day) or vehicle (n=12 each) twice daily from day 28 to day 35, after the onset of the disease. The arthritis severity was recorded as the arthritis score (A) and paw thickness (B). Overtime analysis of arthritis score and paw thickness by 2-way ANOVA revealed significant difference between vehicle group and 4 mg/kg/day grope (p < 0.01). Values are the mean ± SEM. *p < 0.05, **P < 0.01 versus vehicle.