Skip to main content

Table 3 Sensitivity, specificity and area under Receiver Operating Characteristics curve (ROC-area) of index test

From: Low-field magnetic resonance imaging or combined ultrasonography and anti-cyclic citrullinated peptide antibody improve correct classification of individuals as established rheumatoid arthritis: results of a population-based, cross-sectional study

  Standard references
  Historic fulfilment of ACR 1987 criteria Diagnosis by rheumatologist
  Sensitivity Specificity ROC-area Sensitivity Specificity ROC-area
ACR 1987 criteria       
  50 (27-73) 100 (89-100) 75 (64-86) 44 (22-69) 94 (81-99) 69 (57-82)
Adapted ACR 1987 criteria (GS synovitis, US erosions, ACPA)       
  75 (51-91) 97 (84-100) 86 (76-96) 72 (47-90) 91 (77-98) 82 (70-93)
Adapted ACR 1987 criteria (GS synovitis, US erosions, RF)       
  75 (51-91) 94 (80-99) 84 (74-95) 72 (47-90) 87 (73-97) 80 (68-92)
Adapted ACR 1987 criteria (GS synovitis, erosions on radiography, ACPA)       
  60 (36-81) 97 (84-100) 79 (67-91) 56 (31-79) 91 (77-98) 73 (61-86)
Adapted ACR 1987 criteria (PD synovitis, US erosions, ACPA)       
  35 (15-59) 100 (89-100) 67 (57-78) 39 (17-64) 100 (90-100) 69 (58-81)
RAMRIS scale for synovitis       
MCP joints 2-5 (cut-off ≥5) 62 (32-86) 94 (73-100) 78 (63-93) 69 (39-91) 100 (73-100) 85 (72-98)
Combined wrist and MCP joints 2-5 (cut-off ≥10) 62 (32-86) 94 (73-100) 78 (63-93) 62 (32-86) 94 (73-100) 78 (63-93)
  1. Historic fulfilment of the American College of Rheumatology (ACR) 1987 criteria (classification) or diagnosis with rheumatoid arthritis by rheumatologist (diagnosis) as standard reference, % (95% confidence interval). ACPA, anti-cyclic citrullinated peptide antibody; GS, grey-scale; MCP, metacarpophalangeal; PD, Power Doppler; RAMRIS, Rheumatoid Arthritis Magnetic Resonance Imaging scoring System; RF, IgM rheumatoid factor; US, ultrasonography.