Table 2 Results of fixed-effect network meta-analysis and comparison with previous network meta-analysis by Rodgers et al., 2011[16]

PsARC response:

Odds ratio versus placebo OR (95% CrI)

NA

4.28 (2.83, 6.57)^†

9.97 (5.95, 17.08)^†

10.33 (5.84, 19.04)^†

7.74 (4.5, 13.67)^†

Probability (95% CrI)⁺

0.26 (0.22, 0.29)

0.59 (0.48, 0.70)

0.77 (0.66, 0.86)

0.78 (0.66, 0.87)

0.73 (0.60, 0.83)

Comparison with Rodgers 2011 [12]

0.25 (0.18, 0.32)

0.59 (0.44, 0.71)

0.80 (0.67, 0.89)

NA

0.71 (0.57, 0.83)

Change in HAQ conditional on PsARC response

WMD versus placebo non-responders | PsARC responders (95% CrI)*

-0.26 (-0.32, -0.21)^†

-0.49 (-0.58, -0.40)^†

-0.66 (-0.77, -0.55)^†

-0.44 (-0.59, -0.29)^†

-0.64 (-0.77, -0.51)^†

Comparison with Rodgers 2011 [12]

-0.24 (-0.34, -0.15)^†

-0.48 (-0.60, -0.35)^†

-0.66 (-0.79, -0.52)^†

NA

-0.63 (-0.81, -0.46)^†

WMD versus placebo non-responders | PsARC non-responders (95% CrI)*

NA

-0.14 (-0.24, -0.03)^†

-0.20 (-0.31, -0.08)^†

-0.06 (-0.18, 0.06)

-0.20 (-0.35, -0.050)^†

Comparison with Rodgers 2011 [12]

NA

-0.13 (-0.26, -0.00)^†

-0.19 (-0.33, -0.06)^†

NA

-0.19 (-0.381, 0.00)

PASI50

Probability (95% CrI)⁺

0.12 (0.09, 0.16)

0.71 (0.51, 0.86)

0.90 (0.80, 0.96)

0.71 (0.50, 0.87)

0.40 (0.16, 0.73)

Comparison with Rodgers 2011 [12]

0.13 (0.09,0.18)

0.74 (0.55,0.88)

0.91 (0.82,0.97)

NA

0.40 (0.24,0.59)

PASI75

Probability (95% CrI)⁺

0.05 (0.03, 0.07)

0.47 (0.27, 0.68)

0.77 (0.59, 0.89)

0.46 (0.26, 0.70)

0.19 (0.06, 0.49)

Comparison with Rodgers 2011 [12]

0.04 (0.03,0.07)

0.48 (0.28,0.69)

0.77 (0.59,0.90)

NA

0.18 (0.09,0.31)

PASI90

Probability (95% CrI)⁺

0.02 (0.01, 0.03)

0.24 (0.12, 0.44)

0.54 (0.34, 0.75)

0.23 (0.11, 0.46)

0.08 (0.02, 0.26)

Comparison with Rodgers 2011 [12]

0.02 (0.01,0.03)

0.26 (0.12,0.45)

0.56 (0.35,0.77)

NA

0.07 (0.03,0.15)