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Figure 4 | BMC Musculoskeletal Disorders

Figure 4

From: Dose-dependent regulation of cell proliferation and collagen degradation by estradiol on ligamentum flavum

Figure 4

Estradiol regulated the expressions of matrix metalloproteinases. (A) Estradiol significantly increased the expression of MMP-13 at 24 hours (* p <0.05), but not those of MMP-1, MMP-2, and MMP-9 (not shown). (B) & (C) Up-regulation of expression of MMP-13 mRNA (B) and protein (secreted in culture medium) (C) by 10-9 M 17β-estradiol could be attenuated by estrogen receptor antagonist (10-7 M ICI 182780). (n = 6; * p <0.05) (E2: 17β-estradiol; ICI: ICI 182780).

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BMC Musculoskeletal Disorders

ISSN: 1471-2474

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